MicroRNA-targeting therapeutics for hepatitis C
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baek, Jihae | - |
dc.contributor.author | Kang, Soowon | - |
dc.contributor.author | Min, Hyeyoung | - |
dc.date.available | 2019-03-08T22:01:59Z | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12412 | - |
dc.description.abstract | MiR-122 is a liver-specific microRNA (miRNA) that plays a pivotal role in regulating hepatic functions such as lipid metabolism and stress response. The observation that hepatitis C virus (HCV) could only replicate in miR-122-positive hepatocytes led to the discovery that miR-122 is essential for HCV replication, and miR-122 is now one of the crucial host factors for anti-HCV therapy. Currently, the most advanced miR-122 targeting therapy is SPC3649 (miravirsen), a locked nucleic acid-modified oligonucleotide antagonizing miR-122. This review serves to provide information on the discovery and development of SPC3649, the first miRNA-targeted drug to enter human clinical trials, and introduce other miR-122-targeting therapeutics being developed for hepatitis C. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | MicroRNA-targeting therapeutics for hepatitis C | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12272-013-0318-9 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.37, no.3, pp 299 - 305 | - |
dc.identifier.kciid | ART001902109 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000332480600002 | - |
dc.identifier.scopusid | 2-s2.0-84896396537 | - |
dc.citation.endPage | 305 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 299 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 37 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordPlus | VIRUS-INFECTION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | PRIMATES | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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