Hizikia fusiformis fractions successfully improve atopic dermatitis indices in anti-CD3-stimulated splenocytes and 2,4-dinitrochlorobenzene-treated BALB/c mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Kyu Ho | - |
dc.contributor.author | Kim, Hee Jung | - |
dc.contributor.author | Kim, Hae Bok | - |
dc.contributor.author | Kim, Seung Tae | - |
dc.contributor.author | Choi, Young Ri | - |
dc.contributor.author | Seo, Da Woom | - |
dc.contributor.author | Yu, Jung Min | - |
dc.contributor.author | Jang, Su Kil | - |
dc.contributor.author | Kim, Sang Moo | - |
dc.contributor.author | Lee, Do-Ik | - |
dc.contributor.author | Joo, Seong Soo | - |
dc.date.available | 2019-03-08T22:02:32Z | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 0022-3573 | - |
dc.identifier.issn | 2042-7158 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12433 | - |
dc.description.abstract | ObjectivesIn the present study, we aimed to examine whether fractions from an edible sea weed, Hizikia fusiformis, had immunomodulatory effects, particularly an anti-atopic effect, by attenuating the expression of T cell-dependent cytokines using in-vitro and in-vivo animal atopic dermatitis-like models. MethodsThe anti-atopic activities were examined in in vitro, and a 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis-like mouse model using quantitative real-time polymerase chain reaction, electrophoretic-mobility shift and histophathological analysis. Key findingsOur results showed that the final fraction (F2) of H. fusiformis contained a higher amount of butanoic acid which was not found in the other fractions, and effectively inhibited T cell activation by inhibiting dephosphorylation of nuclear factor of activated T cells in electrophoretic-mobility shift assay. As a consequence, helper T cell-dependent cytokines, such as interleukin-2, -4 and interferon-, were significantly inhibited while activated with an anti-CD3 antibody. We also showed that skin challenged with DNCB successfully recovered when treated with 2.5 mg/kg, comparable to that by 0.25% prednicarbate. These results indicate that F2 may contribute to inhibit T cell activation by eliminating Th cell-dependent cytokines. ConclusionsTaken together, we concluded that F2 containing butanoic acid may be a new functional anti-atopic candidate, which probably acts through nuclear factor of activated T cell inactivation mechanisms. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Hizikia fusiformis fractions successfully improve atopic dermatitis indices in anti-CD3-stimulated splenocytes and 2,4-dinitrochlorobenzene-treated BALB/c mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/jphp.12179 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACY AND PHARMACOLOGY, v.66, no.3, pp 466 - 476 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000331357000014 | - |
dc.identifier.scopusid | 2-s2.0-84894228050 | - |
dc.citation.endPage | 476 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 466 | - |
dc.citation.title | JOURNAL OF PHARMACY AND PHARMACOLOGY | - |
dc.citation.volume | 66 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | 2,4-dinitrochlorobenzene | - |
dc.subject.keywordAuthor | atopic dermatitis | - |
dc.subject.keywordAuthor | butanoic acid | - |
dc.subject.keywordAuthor | helper T cell | - |
dc.subject.keywordAuthor | Hizikia fusiformis | - |
dc.subject.keywordPlus | CHAIN FATTY-ACIDS | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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