Hypopigmentary Effects of Ethyl P-Methoxycinnamate Isolated from Kaempferia galanga
DC Field | Value | Language |
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dc.contributor.author | Ko, Hyun-Ju | - |
dc.contributor.author | Kim, Hae Jong | - |
dc.contributor.author | Kim, Su Yeon | - |
dc.contributor.author | Yun, Hye-Young | - |
dc.contributor.author | Baek, Kwang Jin | - |
dc.contributor.author | Kwon, Nyoun Soo | - |
dc.contributor.author | Whang, Wan Kyun | - |
dc.contributor.author | Choi, Hye-Ryung | - |
dc.contributor.author | Park, Kyoung-Chan | - |
dc.contributor.author | Kim, Dong-Seok | - |
dc.date.available | 2019-03-08T22:36:54Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.issn | 1099-1573 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12512 | - |
dc.description.abstract | We isolated crystals from the chloroform fraction of an ethanol extract of Kaempferia galanga and identified it as ethyl p-methoxycinnamate through nuclear magnetic resonance analysis. In the present study, we found that ethyl p-methoxycinnamate significantly decreased melanin synthesis in B16F10 murine melanoma cells stimulated with -melanocyte stimulating hormone (-MSH). In a cell-free system, however, ethyl p-methoxycinnamate did not directly inhibit tyrosinase, the rate-limiting enzyme of melanogenesis. Instead, it inhibited tyrosinase activity in B16F10 cells in a dose-dependent manner. Furthermore, Western blot analysis showed that ethyl p-methoxycinnamate decreased microphthalmia-associated transcription factor and tyrosinase levels in -MSH-stimulated B16F10 cells. These results indicate that the pigment-inhibitory effect of ethyl p-methoxycinnamate results from downregulation of tyrosinase. Ethyl p-methoxycinnamate isolated from K. galanga could be developed as a skin whitening agent to treat hyperpigmentary disorders. Copyright (c) 2013 John Wiley & Sons, Ltd. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Hypopigmentary Effects of Ethyl P-Methoxycinnamate Isolated from Kaempferia galanga | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ptr.4995 | - |
dc.identifier.bibliographicCitation | PHYTOTHERAPY RESEARCH, v.28, no.2, pp 274 - 279 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000330559000018 | - |
dc.identifier.scopusid | 2-s2.0-84893808477 | - |
dc.citation.endPage | 279 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 274 | - |
dc.citation.title | PHYTOTHERAPY RESEARCH | - |
dc.citation.volume | 28 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | melanin | - |
dc.subject.keywordAuthor | Kaempferia galanga | - |
dc.subject.keywordAuthor | ethyl p-methoxycinnamate | - |
dc.subject.keywordAuthor | skin whitening | - |
dc.subject.keywordPlus | MELANIN BIOSYNTHESIS | - |
dc.subject.keywordPlus | SKIN PIGMENTATION | - |
dc.subject.keywordPlus | MELANOGENESIS | - |
dc.subject.keywordPlus | PRINCIPLES | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MITF | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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