Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse
DC Field | Value | Language |
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dc.contributor.author | Choi, Woo Jin | - |
dc.contributor.author | Kim, Seong Keun | - |
dc.contributor.author | Park, Hee Kuk | - |
dc.contributor.author | Sohn, Uy-Dong | - |
dc.contributor.author | Kim, Wonyong | - |
dc.date.available | 2019-03-08T22:37:31Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12537 | - |
dc.description.abstract | Shepherd's purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated the anti-inflammatory and antibacterial properties of a sulforaphane-containing solution (SCS) isolated from shepherd's purse. SCS had significant anti-inflammatory activity indicated by the decreased levels of nitric oxide (NO), cytokines (interleukin 1 beta [IL-1 beta], IL-6, and IL-10), and prostaglandin E-2 (PGE(2)) in lipopolysaccharide-stimulated RAW 264.7 murine macrophages. In addition, SCS decreased the inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) levels, which confirmed the anti- inflammatory activity of S CS. Further, SCS inhibited vancomycin-resistant enterococci (VRE) and Bacillus anthracis. The minimal inhibitory concentration was 250 mu g/ml for VRE and 1,000 mu g/ml for B. anthracis. Taken together, these data indicate that SCS has potential anti-inflammatory and anti-superbacterial properties, and thus it can be used as a functional food or pharmaceutical. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2014.18.1.33 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.18, no.1, pp 33 - 39 | - |
dc.identifier.kciid | ART001854926 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000331593400004 | - |
dc.identifier.scopusid | 2-s2.0-84896538282 | - |
dc.citation.endPage | 39 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Anti-inflammatory effect | - |
dc.subject.keywordAuthor | Antimicrobial activity | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordAuthor | RAW 264.7 murine macrophages | - |
dc.subject.keywordAuthor | Shepherd's purse | - |
dc.subject.keywordAuthor | Sulforaphane | - |
dc.subject.keywordPlus | CAPSELLA-BURSA-PASTORIS | - |
dc.subject.keywordPlus | VANCOMYCIN-RESISTANT ENTEROCOCCI | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | PHENETHYL ISOTHIOCYANATE | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI | - |
dc.subject.keywordPlus | PLANTS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | BROCCOLI | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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