β-catenin mediates the inflammatory cytokine expression induced by the Der p 1 house dust mite allergen
DC Field | Value | Language |
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dc.contributor.author | Jang, Jaewoong | - |
dc.contributor.author | Ha, Jong-Hyeok | - |
dc.contributor.author | Kim, Seok-Min | - |
dc.contributor.author | Kim, Wonyong | - |
dc.contributor.author | Kim, Kijeong | - |
dc.contributor.author | Chung, Sang-In | - |
dc.contributor.author | Yoon, Yoosik | - |
dc.date.available | 2019-03-08T22:38:04Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.issn | 1791-3004 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12564 | - |
dc.description.abstract | The modulations of -catenin were analyzed during the inflammatory response induced by the Der p 1 house dust mite allergen. Der p 1 induced the dose-dependent expression of inflammatory cytokines, including interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor- (TNF-) in THP-1 human monocytic cells. The mRNA expression levels of -catenin were not altered, however protein levels increased following Der p 1 treatment, demonstrating that -catenin was modulated by post-transcriptional processes. It was also revealed that nuclear -catenin levels were significantly increased while cytoplasmic -catenin levels were reduced, which demonstrated the nuclear translocation of -catenin by the Der p 1 allergen. Glycogen synthase kinase 3 (GSK3), a regulator of -catenin stability, was demonstrated to be phosphorylated following Der p 1 treatment. When -catenin was knocked down by the transfection of its small interfering RNA (siRNA), inflammatory cytokine expression as well as nuclear factor-B (NF-B) activity, which were induced by Der p 1 treatment, were all significantly reduced. The results demonstrated that Der p 1-induced inflammatory responses were mediated by beta-catenin. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.title | β-catenin mediates the inflammatory cytokine expression induced by the Der p 1 house dust mite allergen | - |
dc.type | Article | - |
dc.identifier.doi | 10.3892/mmr.2013.1852 | - |
dc.identifier.bibliographicCitation | MOLECULAR MEDICINE REPORTS, v.9, no.2, pp 633 - 638 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000332694100039 | - |
dc.identifier.scopusid | 2-s2.0-84893835825 | - |
dc.citation.endPage | 638 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 633 | - |
dc.citation.title | MOLECULAR MEDICINE REPORTS | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 그리이스 | - |
dc.subject.keywordAuthor | Der p 1 | - |
dc.subject.keywordAuthor | beta-catenin | - |
dc.subject.keywordAuthor | dust mite | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordPlus | RESPIRATORY EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | ASTHMA RISK | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | EOSINOPHILS | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | IL-8 | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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