What Makes a Difference in Exercise-Induced Bronchoconstriction: An 8 Year Retrospective Analysis
DC Field | Value | Language |
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dc.contributor.author | Park, Han-Ki | - |
dc.contributor.author | Jung, Jae-Woo | - |
dc.contributor.author | Cho, Sang-Heon | - |
dc.contributor.author | Min, Kyung-Up | - |
dc.contributor.author | Kang, Hye-Ryun | - |
dc.date.available | 2019-03-08T22:38:22Z | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12575 | - |
dc.description.abstract | Background: Exercise-induced bronchoconstriction (EIB) was recently classified into EIB alone and EIB with asthma, based on the presence of concurrent asthma. Objective: Differences between EIB alone and EIB with asthma have not been fully described. Methods: We retrospectively reviewed who visited an allergy clinic for respiratory symptoms after exercise and underwent exercise bronchial provocation testing. More than a 15% decrease of forced expiratory volume in 1 second (FEV1) from baseline to the end of a 6 min free-running challenge test was interpreted as positive EIB. Results: EIB was observed in 66.9% of the study subjects (89/133). EIB-positive subjects showed higher positivity to methacholine provocation testing (61.4% vs. 18.9%, p<0.001) compared with EIB-negative subjects. In addition, sputum eosinophilia was more frequently observed in EIB-positive subjects than in EIB-negative subjects (56% vs. 23.5%, p = 0.037). The temperature and relative humidity on exercise test day were significantly related with the EIB-positive rate. Positive EIB status was correlated with both temperature (p = 0.001) and relative humidity (p = 0.038) in the methacholine-negative EIB group while such a correlation was not observed in the methacholine-positive EIB group. In the methacholine-positive EIB group the time to reach a 15% decrease in FEV1 during exercise was significantly shorter than that in the methacholine-negative EIB group (3.2 +/- 0.7 min vs. 8.6 +/- 1.6 min, p = 0.004). Conclusions: EIB alone may be a distinct clinical entity from EIB with asthma. Conditions such as temperature and humidity should be considered when performing exercise tests, especially in subjects with EIB alone. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | What Makes a Difference in Exercise-Induced Bronchoconstriction: An 8 Year Retrospective Analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0087155 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.9, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000330617100054 | - |
dc.identifier.scopusid | 2-s2.0-84900457359 | - |
dc.citation.number | 1 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | INDUCED ASTHMA | - |
dc.subject.keywordPlus | INDUCED BRONCHOSPASM | - |
dc.subject.keywordPlus | BRONCHIAL RESPONSIVENESS | - |
dc.subject.keywordPlus | COLD-AIR | - |
dc.subject.keywordPlus | METHACHOLINE | - |
dc.subject.keywordPlus | CHALLENGE | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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