Comparison of the efficacy of 4-and 8-week lansoprazole treatment for ESD-induced gastric ulcers: a randomized, prospective, controlled study
DC Field | Value | Language |
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dc.contributor.author | Park, Ji Hoon | - |
dc.contributor.author | Baek, Eun Kyung | - |
dc.contributor.author | Choi, Chang Hwan | - |
dc.contributor.author | Lee, Kyung Hun | - |
dc.contributor.author | Kim, Beom Jin | - |
dc.contributor.author | Kim, Jeong Wook | - |
dc.contributor.author | Kim, Jae Gyu | - |
dc.contributor.author | Chang, Sae Kyung | - |
dc.date.available | 2019-03-08T22:39:13Z | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 0930-2794 | - |
dc.identifier.issn | 1432-2218 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12615 | - |
dc.description.abstract | Although endoscopic submucosal dissection (ESD) is widely used to treat gastric neoplasms, there is no consensus for the optimal treatment for ESD-induced ulcers. We compared efficacy between 4 and 8 weeks of lansoprazole treatment for iatrogenic gastric ulcers that developed after ESD. Eighty-four patients who were diagnosed with gastric adenoma or early gastric cancer were enrolled and randomly assigned to treatment with lansoprazole (30 mg/day) for 4 or 8 weeks. Eight weeks after ESD, we conducted follow-up endoscopy to compare ulcer stage and ulcer reduction ratio (dividing the ulcer dimension at 8 weeks by the initial ulcer dimension) between the two groups. From the 84 patients, 69 patients were included in the final analysis, with 34 in the 4-week group and 35 in the 8-week group. Eight weeks after ESD, there were no significant difference observed between the two groups in terms of the ulcer stage (68 % in the scar stage in the 4-week group vs. 69 % in the 8-week group, P = 0.93) or the ulcer reduction ratio (0.0081 +/- A 0.015 in the 4-week group vs. 0.0037 +/- A 0.008 in the 8-week group, P = 0.15). Also, in the subgroup analysis among the patients with large ulcers (> 30 mm), those parameters were not different. For ESD-induced gastric ulcers, treatment with lansoprazole for 4 weeks was as effective as treatment for 8 weeks. Considering cost-effectiveness, proton pump inhibitor therapy for 4 weeks may be sufficient for ESD-induced gastric ulcers. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Comparison of the efficacy of 4-and 8-week lansoprazole treatment for ESD-induced gastric ulcers: a randomized, prospective, controlled study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s00464-013-3177-z | - |
dc.identifier.bibliographicCitation | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, v.28, no.1, pp 235 - 241 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000328842700030 | - |
dc.identifier.scopusid | 2-s2.0-84893013460 | - |
dc.citation.endPage | 241 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 235 | - |
dc.citation.title | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | - |
dc.citation.volume | 28 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Endoscopic submucosal dissection | - |
dc.subject.keywordAuthor | Gastric ulcer | - |
dc.subject.keywordAuthor | Proton pump inhibitor | - |
dc.subject.keywordPlus | ENDOSCOPIC SUBMUCOSAL DISSECTION | - |
dc.subject.keywordPlus | PROTON PUMP INHIBITORS | - |
dc.subject.keywordPlus | MUCOSAL BLOOD-FLOW | - |
dc.subject.keywordPlus | CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | PEPTIC-ULCER | - |
dc.subject.keywordPlus | HEALING RATE | - |
dc.subject.keywordPlus | RESECTION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | FAMOTIDINE | - |
dc.subject.keywordPlus | OMEPRAZOLE | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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