Novel inhibitory function of miR-125b in melanogenesis
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyu-Han | - |
dc.contributor.author | Bin, Bum-Ho | - |
dc.contributor.author | Kim, Juewon | - |
dc.contributor.author | Dong, Son Eui | - |
dc.contributor.author | Park, Phil June | - |
dc.contributor.author | Choi, Hyunjung | - |
dc.contributor.author | Kim, Beom Joon | - |
dc.contributor.author | Yu, Seok Jong | - |
dc.contributor.author | Kang, Hyojin | - |
dc.contributor.author | Kang, Hak Hee | - |
dc.contributor.author | Cho, Eun-Gyung | - |
dc.contributor.author | Lee, Tae Ryong | - |
dc.date.available | 2019-03-08T22:39:26Z | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 1755-1471 | - |
dc.identifier.issn | 1755-148X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12623 | - |
dc.description.abstract | MicroRNAs are known to be the important regulators of skin physiology and considered as new therapeutic targets to treat skin diseases. In this study, miR-125b was identified as a potent regulator of steady-state melanogenesis. We found that the expression of miR-125b was inversely related to pigment levels. A miR-125b mimic decreased the expression of pigmentation-related gene and melanin content, implying that miR-125b functions to decrease pigmentation. Moreover, we observed that the reduction in miR-125b expression in pigmented cells was at least partially due to the hypermethylation of the MIR125B-1 promoter, and miR-125b expression was regulated by intracellular cAMP levels. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Novel inhibitory function of miR-125b in melanogenesis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/pcmr.12179 | - |
dc.identifier.bibliographicCitation | PIGMENT CELL & MELANOMA RESEARCH, v.27, no.1, pp 140 - 144 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000328631100020 | - |
dc.identifier.scopusid | 2-s2.0-84890804760 | - |
dc.citation.endPage | 144 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 140 | - |
dc.citation.title | PIGMENT CELL & MELANOMA RESEARCH | - |
dc.citation.volume | 27 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | melanogenesis | - |
dc.subject.keywordAuthor | miR-125b | - |
dc.subject.keywordAuthor | melanoma | - |
dc.subject.keywordAuthor | steady-state | - |
dc.subject.keywordPlus | PROMOTES KERATINOCYTE MIGRATION | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | MICRORNAS | - |
dc.subject.keywordPlus | PSORIASIS | - |
dc.subject.keywordPlus | REGULATORS | - |
dc.subject.keywordPlus | MESSENGER | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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