Anti-inflammatory activity of sulfate-containing phenolic compounds isolated from the leaves of Myrica rubra
DC Field | Value | Language |
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dc.contributor.author | Kim, Han Hyuk | - |
dc.contributor.author | Oh, Myeong Hwan | - |
dc.contributor.author | Park, Kwang Jun | - |
dc.contributor.author | Heo, Jun Hyeok | - |
dc.contributor.author | Lee, Min Won | - |
dc.date.available | 2019-03-08T22:39:52Z | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 0367-326X | - |
dc.identifier.issn | 1873-6971 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12642 | - |
dc.description.abstract | Three sulfated phenolic compounds, juglanin B (11R)-O-sulfate (1), myricetin 3'-O-sulfate (2), and ampelopsin 3'-O-sulfate (3), were isolated from the leaves of Myrica rubra. Compound 1 was a new sulfated lignan, 2 was a new sulfated flavone, and 3 was a known sulfated flavone. The structures of the new compounds (1 and 2) were determined by acid hydrolysis and spectroscopic methods, including IR, FAB-MS, 1D and 2D NMR. The inhibitory activities of compounds 1-3 and their hydrolysates (1a-3a) against LPS-induced cytokine (TNF-alpha, IL-1 beta and IL-6) production in macrophage RAW 264.7 cells were evaluated. The 2 new compounds (1 and 2) and their aglycones (1a and 2a) significantly reduced LPS-induced expression of iNOS and COX-2 proteins. (C) 2013 Published by Elsevier B.V. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Anti-inflammatory activity of sulfate-containing phenolic compounds isolated from the leaves of Myrica rubra | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.fitote.2013.10.007 | - |
dc.identifier.bibliographicCitation | FITOTERAPIA, v.92, pp 188 - 193 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000331420300023 | - |
dc.identifier.scopusid | 2-s2.0-84889588460 | - |
dc.citation.endPage | 193 | - |
dc.citation.startPage | 188 | - |
dc.citation.title | FITOTERAPIA | - |
dc.citation.volume | 92 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Myrica rubra | - |
dc.subject.keywordAuthor | Diarylheptanoid | - |
dc.subject.keywordAuthor | Flavonoid | - |
dc.subject.keywordAuthor | Sulfate | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | RAW 264.7 cells | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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