Self-Assembled Coumarin Nanoparticle in Aqueous Solution as Selective Mitochondrial-Targeting Drug Delivery System
- Authors
- Lee, Ji Ha; Kim, Ka Young; Jin, Hanyong; Baek, Yeong Eun; Choi, Yeonweon; Jung, Sung Ho; Lee, Shim Sung; Bae, Jeehyeon; Jung, Jong Hwa
- Issue Date
- Jan-2018
- Publisher
- AMER CHEMICAL SOC
- Keywords
- aggregation-induced emission; drug delivery; mitochondrial-targeting; fluorescence imaging; aggregation
- Citation
- ACS APPLIED MATERIALS & INTERFACES, v.10, no.4, pp 3380 - 3391
- Pages
- 12
- Journal Title
- ACS APPLIED MATERIALS & INTERFACES
- Volume
- 10
- Number
- 4
- Start Page
- 3380
- End Page
- 3391
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1297
- DOI
- 10.1021/acsami.7b17711
- ISSN
- 1944-8244
1944-8252
- Abstract
- The development of specifically targeted nano particles for subcellular organelles modified with a low molecular-weight organic compound as drug nanocarriers can bring about wide applications in cancer therapy. However, their utility has been hampered by low selectivity, poor biodistribution, and limited efficiency. Herein, we report the aggregation behavior of a triphenylphosphonium-appended coumarin probe (TPP-C) in an aqueous solution and its applications as a mitochondria-targeting probe, and drug delivery carrier, which is a rare example for a low molecular-weight organic compound. The TPP-C formed homogeneous nanoparticles with small diameters in water as well as in mixtures of organic solvents and water. In pure water, the homogeneous nanopartides induced J-aggregation, whereas in mixed solvents, the homogeneous nanoparticles induced H-aggregation. The luminescence intensities of nanoparticles originated from the aggregation-induced emission (ATE) effect in pure water and also in mixtures of organic solvents and water. These findings indicate that the AIE effect of TPP-C was dependent on the solvent. More interestingly, the TPP-C nanoparticles selectively accumulated in mitochondria. The TPP-C nanoparticles alone exhibited noncytotoxicity toward cancer cells. However, with the encapsulation of the anticancer drug doxorubicin (DOX) into the TPP-C nanoparticles, the DOX was efficiently delivered to the mitochondria. These results indicated that the proposed system demonstrates promise as a platform for future clinical medication, particularly for specific suborganelle-targeted drug delivery systems for cancer therapy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
- College of Natural Sciences > Department of Life Science > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1297)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.