Bone Health and Clinical Results after Hip Fracture Surgery in Patients with Subclinical Hypothyroidism

Abstract

Background: Subclinical thyroid dysfunction might influence a bone health. We evalu-ated whether subclinical hypothyroidism adversely affects bone health including bonemineral density (BMD), level of vitamin D, and bone turnover status in patients with hipfracture. Methods: We evaluated 471 patients aged 50 years or older, who underwenthip fracture surgeries. BMD, level of vitamin D, bone turnover status, and one-year mor-tality were compared between subclinical hypothyroidism group and control group. Re-sults: BMD of femur and the level of 25-hydroxy-vitamin D (25-[OH]D) were similar inthe two groups. There were no significant differences in bone turnover markers accord-ing to thyroid function. No significant differences were observed between the groups inutilization of intensive care unit (ICU), length of hospital stay, mobility, and one-yearmortality. Conclusions: Subclinical hypothyroidism was not associated with reducedbone health, including BMD, the level of 25-(OH)D, and bone turnover marker.