Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity: Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis-A Review
DC Field | Value | Language |
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dc.contributor.author | Shin, Eun-Joo | - |
dc.contributor.author | Hai-Quyen Tran | - |
dc.contributor.author | Phuong-Tram Nguyen | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Nah, Seung-Yeol | - |
dc.contributor.author | Jang, Choon-Gon | - |
dc.contributor.author | Nabeshima, Toshitaka | - |
dc.contributor.author | Kim, Hyoung-Chun | - |
dc.date.available | 2019-01-22T14:15:48Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 0364-3190 | - |
dc.identifier.issn | 1573-6903 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1364 | - |
dc.description.abstract | Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies have suggested that impaired mitochondria are critical in dopaminergic toxicity induced by MA. Mitochondria are important energy-producing organelles with dynamic nature. Evidence indicated that exposure to MA can disturb mitochondrial energetic metabolism by inhibiting the Krebs cycle and electron transport chain. Alterations in mitochondrial dynamic processes, including mitochondrial biogenesis, mitophagy, and fusion/fission, have recently been shown to contribute to dopaminergic toxicity induced by MA. Furthermore, it was demonstrated that MA-induced mitochondrial impairment enhances susceptibility to oxidative stress, pro-apoptosis, and neuroinflammation in a positive feedback loop. Protein kinase C delta has emerged as a potential mediator between mitochondrial impairment and oxidative stress, pro-apoptosis, or neuroinflammation in MA neurotoxicity. Understanding the role and underlying mechanism of mitochondrial impairment could provide a molecular target to prevent or alleviate dopaminergic toxicity induced by MA. | - |
dc.format.extent | 13 | - |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | - |
dc.title | Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity: Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis-A Review | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s11064-017-2318-5 | - |
dc.identifier.bibliographicCitation | NEUROCHEMICAL RESEARCH, v.43, no.1, pp 66 - 78 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000419506100008 | - |
dc.identifier.scopusid | 2-s2.0-85020299463 | - |
dc.citation.endPage | 78 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 66 | - |
dc.citation.title | NEUROCHEMICAL RESEARCH | - |
dc.citation.volume | 43 | - |
dc.type.docType | Review | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Methamphetamine | - |
dc.subject.keywordAuthor | Dopaminergic toxicity | - |
dc.subject.keywordAuthor | Mitochondria | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Protein kinase C delta | - |
dc.subject.keywordPlus | KINASE-C-DELTA | - |
dc.subject.keywordPlus | NEUROBLASTOMA SH-SY5Y CELLS | - |
dc.subject.keywordPlus | DISMUTASE TRANSGENIC MICE | - |
dc.subject.keywordPlus | ELECTRON-TRANSPORT CHAIN | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | ZINC SUPEROXIDE-DISMUTASE | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | MOUSE-BRAIN | - |
dc.subject.keywordPlus | MICROGLIAL ACTIVATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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