Functional poly(l-lysine) derivative nanogels with acidic pH-pulsed antitumor drug release properties
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, M.J. | - |
dc.contributor.author | Oh, N.M. | - |
dc.contributor.author | Oh, K.T. | - |
dc.contributor.author | Youn, Y.S. | - |
dc.contributor.author | Lee, E.S. | - |
dc.date.available | 2019-03-09T00:38:32Z | - |
dc.date.issued | 2014-10-01 | - |
dc.identifier.issn | 2093-5552 | - |
dc.identifier.issn | 2093-6214 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/13791 | - |
dc.description.abstract | We developed novel poly(l-lysine) [poly(Lys)] derivative nanogels with smart drug release properties. Poly(Lys) derivative was prepared after the chemical reaction of poly(Lys) and 3-diethylaminopropyl isothiocyanate (DEAP), and was coupled with poly(ethylene glycol) (PEG). The obtained poly(Lys-DEAP)-b-PEG was crosslinked by genipin (crosslinking agent) in an oil/water emulsion condition, producing poly(Lys) derivative nanogels. These nanogels (~95 nm in diameter, pH 7.4) showed volume expansion (~200 nm in diameter) in the endosomal pH (~pH 6.0) due to extensive proton absorption of DEAP moieties in the crosslinked nanogel core. These nanogels reversibly swelled at pH 6.0 and shrank at pH 7.4, correspond to maximized drug release at pH 6.0 and minimized drug release at pH 7.4. We conclude that this nanogel system will have great potential for tumor therapy. © 2014, The Korean Society of Pharmaceutical Sciences and Technology. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Kluwer Academic Publishers | - |
dc.title | Functional poly(l-lysine) derivative nanogels with acidic pH-pulsed antitumor drug release properties | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s40005-014-0130-7 | - |
dc.identifier.bibliographicCitation | Journal of Pharmaceutical Investigation, v.44, no.5, pp 351 - 356 | - |
dc.identifier.kciid | ART001921533 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84907191114 | - |
dc.citation.endPage | 356 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 351 | - |
dc.citation.title | Journal of Pharmaceutical Investigation | - |
dc.citation.volume | 44 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | 3-(Diethylamino)propyl | - |
dc.subject.keywordAuthor | Antitumor drug delivery | - |
dc.subject.keywordAuthor | Genipin | - |
dc.subject.keywordAuthor | pH-Responsive nanogels | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.