Growth hormone-releaser diet attenuates cognitive dysfunction in klotho mutant mice via insulin-like growth factor-1 receptor activation in a genetic aging model
DC Field | Value | Language |
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dc.contributor.author | Park, S.J. | - |
dc.contributor.author | Chung, Y.H. | - |
dc.contributor.author | Lee, J.H. | - |
dc.contributor.author | Dang, D.-K. | - |
dc.contributor.author | Nam, Y. | - |
dc.contributor.author | Jeong, J.H. | - |
dc.contributor.author | Kim, Y.S. | - |
dc.contributor.author | Nabeshima, T. | - |
dc.contributor.author | Shin, E.-J. | - |
dc.contributor.author | Kim, H.-C. | - |
dc.date.available | 2019-03-09T00:39:20Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.issn | 2093-5978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/13822 | - |
dc.description.abstract | Background: It has been recognized that a defect in klotho gene expression accelerates the degeneration of multiple age-sensitive traits. Accumulating evidence indicates that aging is associated with declines in cognitive function and the activity of growth hormone (GH)/insulin-like growth factor-1 (IGF-1). Methods: In this study, we examined whether a GH-releaser diet could be effective in protecting against cognitive impairment in klotho mutant mice. Results: The GH-releaser diet significantly induced the expression of IGF-1 and IGF-1 receptors in the hippocampus of klotho mutant mice. Klotho mutant mice showed significant memory impairments as compared with wild-type mice. In addition, the klotho mutation significantly decreased the expression of cell survival/antiapoptotic factors, including phospho-Akt (p-Akt)/phospho- glycogen synthase kinase3β (p-GSK3β), phospho-extracellular signal-related kinase (p-ERK), and Bcl-2, but significantly increased those of cell death/proapoptotic factors, such as phospho-c-jun N-terminal kinase (p-JNK), Bax, and cleaved caspase-3 in the hippocampus. Treatment with GH-releaser diet significantly attenuated both decreases in the expression of cell survival/antiapoptotic factors and increases in the expression of cell death/proapoptotic factors in the hippocampus of klotho mutant mice. In addition, klotho mutation-induced oxidative stress was significantly attenuated by the GH-releaser diet. Consequently, a GH-releaser diet significantly improved memory function in the klotho mutant mice. GH-releaser diet-mediated actions were significantly reversed by JB-1, an IGF-1 receptor antagonist. Conclusion: The results suggest that a GH-releaser diet attenuates oxidative stress, proapoptotic changes and consequent dysfunction in klotho mutant mice by promoting IGF-1 expression and IGF-1 receptor activation. © 2014 Korean Endocrine Society. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Endocrine Society | - |
dc.title | Growth hormone-releaser diet attenuates cognitive dysfunction in klotho mutant mice via insulin-like growth factor-1 receptor activation in a genetic aging model | - |
dc.type | Article | - |
dc.identifier.doi | 10.3803/EnM.2014.29.3.336 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism, v.29, no.3, pp 336 - 348 | - |
dc.identifier.kciid | ART001920396 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-84930707027 | - |
dc.citation.endPage | 348 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 336 | - |
dc.citation.title | Endocrinology and Metabolism | - |
dc.citation.volume | 29 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Cognitive dysfunction | - |
dc.subject.keywordAuthor | GH-releaser diet | - |
dc.subject.keywordAuthor | Klotho gene | - |
dc.subject.keywordAuthor | Receptor, IGF type 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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