COGNITION AND MEMORY FUNCTION OF TARAXACUM COREANUM IN AN IN VIVO AMYLOID-B-INDUCED MOUSE MODEL OF ALZHEIMER'S DISEASE
DC Field | Value | Language |
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dc.contributor.author | Lee, Ah Young | - |
dc.contributor.author | Yamabe, Noriko | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.contributor.author | Cho, Eun Ju | - |
dc.date.available | 2019-03-09T00:56:58Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0354-4664 | - |
dc.identifier.issn | 1821-4339 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14011 | - |
dc.description.abstract | We investigated whether the ethyl acetate fraction of Taraxacum coreanum (ETC) had a protective effect against memory impairment in an amyloid beta (A beta)-induced mouse model of Alzheimer's disease (AD). The formation of A beta in the brain is a hallmark of AD. We examined whether oxidative stress contributes to learning and memory deficits using the T-maze test, the object recognition test, and the Morris water maze test in mice injected with A beta. Cognition and memory function were significantly impaired in mice injected with A beta, as compared to the normal group. However, mice that received ETC orally at doses of 50 or 100 mg/kg/day for 2 weeks showed high recognition behavior of tasks. ETC may have prevented oxidative stress to the brain tissue by reducing lipid peroxidation levels and a NO scavenger. ETC could be useful for the prevention and treatment of AD. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | INST BIOLOSKA ISTRAZIVANJA SINISA STANKOVIC | - |
dc.title | COGNITION AND MEMORY FUNCTION OF TARAXACUM COREANUM IN AN IN VIVO AMYLOID-B-INDUCED MOUSE MODEL OF ALZHEIMER'S DISEASE | - |
dc.type | Article | - |
dc.identifier.doi | 10.2298/ABS1404357L | - |
dc.identifier.bibliographicCitation | ARCHIVES OF BIOLOGICAL SCIENCES, v.66, no.4, pp 1357 - 1366 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000346477900008 | - |
dc.identifier.scopusid | 2-s2.0-84921637969 | - |
dc.citation.endPage | 1366 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1357 | - |
dc.citation.title | ARCHIVES OF BIOLOGICAL SCIENCES | - |
dc.citation.volume | 66 | - |
dc.type.docType | Article | - |
dc.publisher.location | 세르비아공화국 | - |
dc.subject.keywordAuthor | Taraxacum coreanum | - |
dc.subject.keywordAuthor | Alzheimer's disease | - |
dc.subject.keywordAuthor | cognition | - |
dc.subject.keywordAuthor | memory | - |
dc.subject.keywordPlus | BETA-PEPTIDE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | NEURODEGENERATIVE DISORDERS | - |
dc.subject.keywordPlus | CHOLINERGIC DYSFUNCTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DEFICITS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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