Home cage locomotor changes in non-human primates after prolonged welding-fume exposure
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Choong Yong | - |
dc.contributor.author | Sung, Jae Hyuck | - |
dc.contributor.author | Chung, Yong Hyun | - |
dc.contributor.author | Park, Jung Duck | - |
dc.contributor.author | Han, Jeong Hee | - |
dc.contributor.author | Lee, Jong Seong | - |
dc.contributor.author | Heo, Jeong Doo | - |
dc.contributor.author | Yu, Il Je | - |
dc.date.available | 2019-03-09T00:58:22Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 0895-8378 | - |
dc.identifier.issn | 1091-7691 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14075 | - |
dc.description.abstract | To define the relationship between the brain concentration of manganese and neurological signs, such as locomotion, after prolonged welding-fume exposure, cynomolgus monkeys were acclimated for 1 month and then divided into three concentration groups: unexposed, low concentration (31 mg/m(3) total suspended particulate (TSP), 0.9 mg/m(3) of Mn), and high concentration (62 mg/m(3) TSP, 1.95 mg/m(3) of Mn) of TSP. The monkeys were exposed to manual metal-arc stainless steel (MMA-SS) welding fumes for 2 h per day over 8 months in an inhalation chamber system equipped with an automatic fume generator. The home cage locomotor activity and patterns were determined using a camera system over 2-4 consecutive days. After 25 and 32 weeks of exposure, the home cage locomotor activity of the high-concentration primates was found to be 5-6 times higher than that of the unexposed primates, and this increased locomotor activity was maintained for 7 weeks after ceasing the welding-fume exposure, eventually subsiding to three times higher after 13 weeks of recovery. Therefore, the present results, along with our previous observations of a high magnetic resonance imaging (MRI) T1 signal in the globus pallidus and increased blood Mn concentration, indicate that prolonged welding-fume exposure can cause neurobehavioral changes in cynomolgus monkeys. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | INFORMA HEALTHCARE | - |
dc.title | Home cage locomotor changes in non-human primates after prolonged welding-fume exposure | - |
dc.type | Article | - |
dc.identifier.doi | 10.3109/08958378.2013.849316 | - |
dc.identifier.bibliographicCitation | INHALATION TOXICOLOGY, v.25, no.14, pp 794 - 801 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000327889900005 | - |
dc.identifier.scopusid | 2-s2.0-84889667046 | - |
dc.citation.endPage | 801 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 794 | - |
dc.citation.title | INHALATION TOXICOLOGY | - |
dc.citation.volume | 25 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Behavior | - |
dc.subject.keywordAuthor | manganese | - |
dc.subject.keywordAuthor | MRI | - |
dc.subject.keywordAuthor | non-human primate | - |
dc.subject.keywordAuthor | welding-fume | - |
dc.subject.keywordPlus | BLOOD MANGANESE CONCENTRATION | - |
dc.subject.keywordPlus | SPRAGUE-DAWLEY RATS | - |
dc.subject.keywordPlus | SIGNAL INTENSITIES | - |
dc.subject.keywordPlus | CYNOMOLGUS MONKEYS | - |
dc.subject.keywordPlus | FERROALLOY PLANT | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | LUNG FIBROSIS | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | WORKERS | - |
dc.subject.keywordPlus | IRON | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.