IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ock, Sangmi | - |
dc.contributor.author | Ahn, Jihyun | - |
dc.contributor.author | Lee, Seok Hong | - |
dc.contributor.author | Kang, Hyun | - |
dc.contributor.author | Offermanns, Stefan | - |
dc.contributor.author | Ahn, Hwa Young | - |
dc.contributor.author | Jo, Young Suk | - |
dc.contributor.author | Shong, Minho | - |
dc.contributor.author | Cho, Bo Youn | - |
dc.contributor.author | Jo, Daewoong | - |
dc.contributor.author | Abel, E. Dale | - |
dc.contributor.author | Lee, Tae Jin | - |
dc.contributor.author | Park, Woo Jin | - |
dc.contributor.author | Lee, In-Kyu | - |
dc.contributor.author | Kim, Jaetaek | - |
dc.date.available | 2019-03-09T00:59:10Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.issn | 1530-6860 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14110 | - |
dc.description.abstract | Although thyroid-stimulating hormone (TSH) is known to be a major regulator of thyroid hormone biosynthesis and thyroid growth, insulin-like growth factor 1 (IGF-1) is required for mediating thyrocyte growth in concert with TSH in vitro. We generated mice with thyrocyte-selective ablation of IGF-1 receptor (TIGF1RKO) to explore the role of IGF-1 receptor signaling on thyroid function and growth. In 5-wk-old TIGF1RKO mice, serum thyroxine (T-4) concentrations were decreased by 30% in concert with a 43% down-regulation of the monocarboxylate transporter 8 (MCT8), which is involved in T-4 secretion. Despite a 3.5-fold increase in circulating concentrations of TSH, thyroid architecture and size were normal. Furthermore, thyrocyte area was increased by 40% in WT thyroids after 10 d TSH injection, but this effect was absent in TSH-injected TIGF1RKO mice. WT mice treated with methimazole and sodium perchlorate for 2 or 6 wk exhibited pronounced goiter development (2.0 and 5.4-fold, respectively), but in TIGF1RKO mice, goiter development was completely abrogated. These data reveal an essential role for IGF-1 receptor signaling in the regulation of thyroid function and TSH-stimulated goitrogenesis. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.title | IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter | - |
dc.type | Article | - |
dc.identifier.doi | 10.1096/fj.13-231381 | - |
dc.identifier.bibliographicCitation | FASEB JOURNAL, v.27, no.12, pp 4899 - 4908 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000329999000024 | - |
dc.identifier.scopusid | 2-s2.0-84890518350 | - |
dc.citation.endPage | 4908 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 4899 | - |
dc.citation.title | FASEB JOURNAL | - |
dc.citation.volume | 27 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | MCT8 | - |
dc.subject.keywordAuthor | T-4 | - |
dc.subject.keywordAuthor | hypertrophy | - |
dc.subject.keywordAuthor | proliferation | - |
dc.subject.keywordPlus | GROWTH-FACTOR-I | - |
dc.subject.keywordPlus | FOLLICULAR CELLS | - |
dc.subject.keywordPlus | FRTL-5 CELLS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | THYROTROPIN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | GLAND | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ABSENCE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.