Detailed Information

Cited 19 time in webofscience Cited 20 time in scopus
Metadata Downloads

Anti-Inflammatory and Anti-Oxidative Nutrition in Hypoalbuminemic Dialysis Patients (AIONID) study: results of the pilot-feasibility, double-blind, randomized, placebo-controlled trial

Full metadata record
DC Field Value Language
dc.contributor.authorRattanasompattikul, Manoch-
dc.contributor.authorMolnar, Miklos Z.-
dc.contributor.authorLee, Martin L.-
dc.contributor.authorDukkipati, Ramanath-
dc.contributor.authorBross, Rachelle-
dc.contributor.authorJing, Jennie-
dc.contributor.authorKim, Youngmee-
dc.contributor.authorVoss, Anne C.-
dc.contributor.authorBenner, Debbie-
dc.contributor.authorFeroze, Usama-
dc.contributor.authorMacDougall, Iain C.-
dc.contributor.authorTayek, John A.-
dc.contributor.authorNorris, Keith C.-
dc.contributor.authorKopple, Joel D.-
dc.contributor.authorUnruh, Mark-
dc.contributor.authorKovesdy, Csaba P.-
dc.contributor.authorKalantar-Zadeh, Kamyar-
dc.date.available2019-03-09T00:59:19Z-
dc.date.issued2013-12-
dc.identifier.issn2190-5991-
dc.identifier.issn2190-6009-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14116-
dc.description.abstractBackground Low serum albumin is common and associated with protein-energy wasting, inflammation, and poor outcomes in maintenance hemodialysis (MHD) patients. We hypothesized that in-center (in dialysis clinic) provision of high-protein oral nutrition supplements (ONS) tailored for MHD patients combined with anti-oxidants and anti-inflammatory ingredients with or without an anti-inflammatory appetite stimulator (pentoxifylline, PTX) is well tolerated and can improve serum albumin concentration. Methods Between January 2008 and June 2010, 84 adult hypoalbuminemic (albumin < 4.0 g/dL) MHD outpatients were double-blindly randomized to receive 16 weeks of interventions including ONS, PTX, ONS with PTX, or placebos.Nutritional and inflammatory markers were compared between the four groups. Results Out of 84 subjects (mean +/- SD; age, 59 +/- 12 years; vintage, 34 +/- 34 months), 32 % were Blacks, 54 % females, and 68 % diabetics. ONS, PTX, ONS plus PTX, and placebo were associated with an average change in serum albumin of +0.21 (P= 0.004), +0.14 (P= 0.008), +0.18 (P= 0.001), and +0.03 g/dL (P= 0.59), respectively. No related serious adverse events were observed. In a predetermined intention-to-treat regression analysis modeling post-trial serum albumin as a function of pre-trial albumin and the three different interventions (ref = placebo), only ONS without PTX was associated with a significant albumin rise (+0.17 +/- 0.07 g/dL, P= 0.018). Conclusions In this pilot-feasibility, 2x2 factorial, placebocontrolled trial, daily intake of a CKD-specific high-protein ONS with anti-inflammatory and anti-oxidative ingredients for up to 16 weeks was well tolerated and associated with slight but significant increase in serum albumin levels. Larger long-term controlled trials to examine hard outcomes are indicated.-
dc.format.extent11-
dc.language영어-
dc.language.isoENG-
dc.publisherSPRINGER HEIDELBERG-
dc.titleAnti-Inflammatory and Anti-Oxidative Nutrition in Hypoalbuminemic Dialysis Patients (AIONID) study: results of the pilot-feasibility, double-blind, randomized, placebo-controlled trial-
dc.typeArticle-
dc.identifier.doi10.1007/s13539-013-0115-9-
dc.identifier.bibliographicCitationJOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v.4, no.4, pp 247 - 257-
dc.description.isOpenAccessY-
dc.identifier.wosid000330218400002-
dc.identifier.scopusid2-s2.0-84876718554-
dc.citation.endPage257-
dc.citation.number4-
dc.citation.startPage247-
dc.citation.titleJOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE-
dc.citation.volume4-
dc.type.docTypeArticle-
dc.publisher.location독일-
dc.subject.keywordAuthorAlbumin-
dc.subject.keywordAuthorHypoalbuminemia-
dc.subject.keywordAuthorInflammation-
dc.subject.keywordAuthorProtein intake-
dc.subject.keywordAuthorHemodialysis-
dc.subject.keywordAuthorOral nutrition supplements-
dc.subject.keywordAuthorAnti-oxidant ingredients-
dc.subject.keywordAuthorAnti-inflammatory ingredients-
dc.subject.keywordPlusCHRONIC KIDNEY-DISEASE-
dc.subject.keywordPlusCHRONIC-RENAL-FAILURE-
dc.subject.keywordPlusGAMMA-LINOLENIC ACID-
dc.subject.keywordPlusATHEROSCLEROSIS MIA SYNDROME-
dc.subject.keywordPlusHEMODIALYSIS-PATIENTS-
dc.subject.keywordPlusSERUM-ALBUMIN-
dc.subject.keywordPlusEICOSAPENTAENOIC ACID-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusMALNUTRITION-
dc.subject.keywordPlusPROTEIN-
dc.relation.journalResearchAreaGeriatrics & Gerontology-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryGeriatrics & Gerontology-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Files in This Item
There are no files associated with this item.
Appears in
Collections
Red Cross College of Nursing > Department of Nursing > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Youngmee photo

Kim, Youngmee
적십자간호대학 (간호학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE