pH-dependent sustained release characteristics of disulfide polymers prepared by simple thermal polymerization
- Authors
- Park, Chul Ho; Lee, Jonghwi
- Issue Date
- 1-Nov-2013
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- lipoic acid; polymerization; disulfide polymer; sustainable release; pH-dependent degradation; hydrogel
- Citation
- JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.24, no.16, pp 1848 - 1857
- Pages
- 10
- Journal Title
- JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
- Volume
- 24
- Number
- 16
- Start Page
- 1848
- End Page
- 1857
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14149
- DOI
- 10.1080/09205063.2013.807458
- ISSN
- 0920-5063
1568-5624
- Abstract
- Biocompatible polymers have played an integral role in the advancement of drug delivery systems. The discovery of a novel polymer with innovative properties can provide great opportunities to enhance drug efficacy as well as reduce side effects. In this study, a novel disulfide polymer was synthesized and characterized. Its monomer is alpha-lipoic acid (ALA), which is synthesized in all cells in the human body. The disulfide polymer was obtained by the simple thermal polymerization of crystalline particles at a temperature higher than its melting point, followed by precipitation purification. It had rubbery and sticky characteristics. In vitro release tests demonstrated that the disulfide polymer had both pH-dependent degradation and related sustained release profiles, with a degraded form of ALA. Therefore, this novel class of responsive polymers that can be prepared by simple thermal polymerization has pronounced potential to contribute to future drug delivery systems.
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Collections - College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
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