Nitric oxide integrated polyethylenimine-based tri-block copolymer for efficient antibacterial activity
DC Field | Value | Language |
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dc.contributor.author | Park, Junghong | - |
dc.contributor.author | Kim, Jihoon | - |
dc.contributor.author | Singha, Kaushik | - |
dc.contributor.author | Han, Dong-Keun | - |
dc.contributor.author | Park, Hansoo | - |
dc.contributor.author | Kim, Won Jong | - |
dc.date.available | 2019-03-09T01:00:07Z | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14151 | - |
dc.description.abstract | The work demonstrated a successful synthesis of nitric oxide (NO)-releasing material and its antibacterial effect on Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA). The polymeric support composed of thermosensitive Pluronic F68 having good biocompatibility and branched polyethylenimine (BPEI) housed N-diazeniumdiolates (NONOates) which could store and release NO under appropriate physiological condition. The developed F68-BPEI-NONOates releases a sufficient amount of NO under physiological condition to elicit effective killing of E. coli, S. aureus and MRSA. The antibacterial ability of the released NO was compared to un-treated control or unmodified F68 polymer by using confocal microscopy; F68-BPEI-NONOates demonstrated excellent antibacterial activity with in vitro low cytotoxicity. TEM investigation also revealed the destruction of bacteria membrane caused by NO. The effectiveness of F68-BPEI-NONOates against resistant strains such as MRSA provides a very simple but highly efficient strategy to combat drug-resistant bacterial infections. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Nitric oxide integrated polyethylenimine-based tri-block copolymer for efficient antibacterial activity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2013.07.064 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.34, no.34, pp 8766 - 8775 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000324450600021 | - |
dc.identifier.scopusid | 2-s2.0-84882814101 | - |
dc.citation.endPage | 8775 | - |
dc.citation.number | 34 | - |
dc.citation.startPage | 8766 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 34 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | N-Diazeniumdiolates | - |
dc.subject.keywordAuthor | Nitric oxide delivery | - |
dc.subject.keywordAuthor | Antibacterial activity | - |
dc.subject.keywordAuthor | Methicillin-resistance | - |
dc.subject.keywordPlus | RESISTANT STAPHYLOCOCCUS-AUREUS | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | ANTIMICROBIAL ACTIVITY | - |
dc.subject.keywordPlus | SILVER NANOPARTICLES | - |
dc.subject.keywordPlus | MUSCLE-CELLS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | PEROXYNITRITE | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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