The effect of calcium phosphate cement-silica composite materials on proliferation and differentiation of pre-osteoblast cells
DC Field | Value | Language |
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dc.contributor.author | Ahn, Geunseon | - |
dc.contributor.author | Lee, Jae Yeon | - |
dc.contributor.author | Seol, Dai-Wu | - |
dc.contributor.author | Pyo, Sung Gyu | - |
dc.contributor.author | Lee, Donghyun | - |
dc.date.available | 2019-03-09T01:01:45Z | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 0167-577X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14216 | - |
dc.description.abstract | Calcium phosphate cement (CPC) is increasingly being used for bone and tissue engineering in the medical and dental fields. In the current study, we investigated the ability of a CPC-silica composite to enhance the activity of cells by analyzing its effects on the proliferation and differentiation of MC3T3-E1, an osteoblast precursor cell line. We found that the CPC-silica composite materials with low silica content (5 wt%) promoted good initial cell adhesion and proliferation. In addition, the CPC-silica composite materials exhibited a higher capacity for stimulating osteogenic differentiation, which was assayed using alkaline phosphatase (ALP) activity and RT-PCR, than CPC alone. Therefore, we propose that 5 wt% silica content may serve as a useful component in calcium phosphate-based bone cements owing to its ability to promote osteoblast differentiation. (c) 2013 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | The effect of calcium phosphate cement-silica composite materials on proliferation and differentiation of pre-osteoblast cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.matlet.2013.07.110 | - |
dc.identifier.bibliographicCitation | MATERIALS LETTERS, v.109, pp 302 - 305 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000324902000077 | - |
dc.identifier.scopusid | 2-s2.0-84882765115 | - |
dc.citation.endPage | 305 | - |
dc.citation.startPage | 302 | - |
dc.citation.title | MATERIALS LETTERS | - |
dc.citation.volume | 109 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Calcium phosphate cement | - |
dc.subject.keywordAuthor | Silica | - |
dc.subject.keywordAuthor | MC3T3-E1 | - |
dc.subject.keywordAuthor | Proliferation | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | TCP | - |
dc.subject.keywordPlus | GEL | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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