Antiviral activity of ginsenoside Rg3 isomers against gammaherpesvirus through inhibition of p38-and JNK-associated pathways
DC Field | Value | Language |
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dc.contributor.author | Kang, Soowon | - |
dc.contributor.author | Song, Moon Jung | - |
dc.contributor.author | Min, Hyeyoung | - |
dc.date.available | 2019-01-22T14:16:17Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1424 | - |
dc.description.abstract | Natural compounds from functional foods targeting viruses are considered to have important role for regulating virus-related diseases. Ginsenoside Rg3 is one of the active pharmaceutical components found in Panax ginseng C.A. Meyer which is widely used as a functional food in East Asia. In our present study, we have characterized the antiviral activities of the ginsenoside Rg3 isomers, 20(R)- and 20(S)-ginsenoside Rg3, against murine gammaherpesvirus 68 (MHV-68), a mouse model of human gammaherpesvirus which can cause various malignancies including cancer. We found that both 20(R)- and 20(S)-ginsenoside Rg3 inhibited lytic replication and viral proliferation of MHV-68, although 20(S)-ginsenoside Rg3 was more effective than 20(R)-ginsenoside Rg3. Furthermore, ginsenoside Rg3 isomers efficiently repressed chemically-induced lytic replication of human gammaherpesviruses in EBV-positive BC-3 and KSHV-positive Raji cell lines. Finally, our data showed that ginsenoside Rg3 isomers suppressed the p38 and/or the JNK-associated MAPK signaling pathways, thereby inhibiting viral replication. | - |
dc.format.extent | 10 | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Antiviral activity of ginsenoside Rg3 isomers against gammaherpesvirus through inhibition of p38-and JNK-associated pathways | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jff.2017.11.011 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.40, pp 219 - 228 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000428005500024 | - |
dc.identifier.scopusid | 2-s2.0-85034103665 | - |
dc.citation.endPage | 228 | - |
dc.citation.startPage | 219 | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 40 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Panax ginseng | - |
dc.subject.keywordAuthor | Ginsenoside Rg3 | - |
dc.subject.keywordAuthor | Antiviral activity | - |
dc.subject.keywordAuthor | Gammaherpesvirus | - |
dc.subject.keywordAuthor | MAP Kinases | - |
dc.subject.keywordPlus | SARCOMA-ASSOCIATED HERPESVIRUS | - |
dc.subject.keywordPlus | EPSTEIN-BARR-VIRUS | - |
dc.subject.keywordPlus | PROTEIN-KINASE PATHWAYS | - |
dc.subject.keywordPlus | KOREAN RED GINSENG | - |
dc.subject.keywordPlus | LYTIC REPLICATION CYCLE | - |
dc.subject.keywordPlus | KAPOSIS-SARCOMA | - |
dc.subject.keywordPlus | MURINE GAMMAHERPESVIRUS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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