Differences between asthma in young and elderly: Results from the COREA study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Heung-Woo | - |
dc.contributor.author | Kwon, Hyouk-Soo | - |
dc.contributor.author | Kim, Tae-Bum | - |
dc.contributor.author | Kim, Sang-Heon | - |
dc.contributor.author | Chang, Yoon-Seok | - |
dc.contributor.author | Jang, An-Soo | - |
dc.contributor.author | Cho, You-Sook | - |
dc.contributor.author | Nahm, Dong-Ho | - |
dc.contributor.author | Park, Jung-Won | - |
dc.contributor.author | Yoon, Ho-Joo | - |
dc.contributor.author | Cho, Young-Joo | - |
dc.contributor.author | Choi, Byoung Whui | - |
dc.contributor.author | Moon, Hee-Bom | - |
dc.contributor.author | Cho, Sang-Heon | - |
dc.date.available | 2019-03-09T01:03:02Z | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 0954-6111 | - |
dc.identifier.issn | 1532-3064 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14265 | - |
dc.description.abstract | Background: There has been no large-scale and comprehensive study of the differences between asthma in elderly asthmatics (EA) and non-elderly (i.e. young) asthmatics (NEA). Methods: We performed principal component analysis (PCA) using 2067 asthmatics (434 EA and 1633 NEA) from the Korean Cohort for Reality and Evolution of adult Asthma (COREA). EA was defined as asthmatics with the chronological age of 65 or more and eleven clinical variables measured at enrollment were used for PCA; symptom score, symptom duration, number of exacerbation during previous one year, smoking pack year, number of controller medications, body mass index, predicted % of FEV1, predicted % FVC, post-bronchodilator FEV1/FVC ratio, atopy index and number of eosinophils in peripheral blood. Results: PCA of all asthmatics showed that EA and NEA were distinctly separated by the first and second principal component on the plot of individual asthmatics according to their scores. For further analysis, we divided all asthmatics into the EA and the NEA group and performed PCA again in each group. The first four principal components with eigenvalues >= 1.0 were identified in both groups and they explained 55.5% of the variance in the EA group and 52.4% in the NEA group respectively. Clinical variables showed distinctly different patterns of loading on the first four principal components between the EA and the NEA group. Conclusion: EA and NEA have different compositional patterns underlying their clinical variables. These observations helped in understanding the differences between EA and NEA from the integrated view covering various clinical aspects. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | W B SAUNDERS CO LTD | - |
dc.title | Differences between asthma in young and elderly: Results from the COREA study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.rmed.2013.07.016 | - |
dc.identifier.bibliographicCitation | RESPIRATORY MEDICINE, v.107, no.10, pp 1509 - 1514 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000326305000005 | - |
dc.identifier.scopusid | 2-s2.0-84884816843 | - |
dc.citation.endPage | 1514 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1509 | - |
dc.citation.title | RESPIRATORY MEDICINE | - |
dc.citation.volume | 107 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | Elderly | - |
dc.subject.keywordAuthor | Characteristics | - |
dc.subject.keywordAuthor | Principal components analysis | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | SENSITIZATION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | OLDER | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.