Inhibition of Xenograft Tumor Growth by Gold Nanoparticle-DNA Oligonucleotide Conjugates-Assisted Delivery of BAX mRNA
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeom, Ji-Hyun | - |
dc.contributor.author | Ryou, Sang-Mi | - |
dc.contributor.author | Won, Miae | - |
dc.contributor.author | Park, Mira | - |
dc.contributor.author | Bae, Jeehyeon | - |
dc.contributor.author | Lee ,Kangseok | - |
dc.date.available | 2019-03-09T01:36:37Z | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14292 | - |
dc.description.abstract | Use of non-biological agents for mRNA delivery into living systems in order to induce heterologous expression of functional proteins may provide more advantages than the use of DNA and/or biological vectors for delivery. However, the low efficiency of mRNA delivery into live animals, using non-biological systems, has hampered the use of mRNA as a therapeutic molecule. Here, we show that gold nanoparticle-DNA oligonucleotide (AuNP-DNA) conjugates can serve as universal vehicles for more efficient delivery of mRNA into human cells, as well as into xenograft tumors generated in mice. Injections of BAX mRNA loaded on AuNP-DNA conjugates into xenograft tumors resulted in highly efficient mRNA delivery. The delivered mRNA directed the efficient production of biologically functional BAX protein, a pro-apoptotic factor, consequently inhibiting tumor growth. These results demonstrate that mRNA delivery by AuNP-DNA conjugates can serve as a new platform for the development of safe and efficient gene therapy. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Inhibition of Xenograft Tumor Growth by Gold Nanoparticle-DNA Oligonucleotide Conjugates-Assisted Delivery of BAX mRNA | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0075369 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.8, no.9 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000324768000073 | - |
dc.identifier.scopusid | 2-s2.0-84884485314 | - |
dc.citation.number | 9 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | PROTEIN EXPRESSION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRANSFECTION | - |
dc.subject.keywordPlus | PROSPECTS | - |
dc.subject.keywordPlus | VECTORS | - |
dc.subject.keywordPlus | LIPIDS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.