The Ca2+ channel inhibitor efonidipine decreases voltage-dependent K+ channel activity in rabbit coronary arterial smooth muscle cells
DC Field | Value | Language |
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dc.contributor.author | Park, Mi-Hyeong | - |
dc.contributor.author | Son, Youn Kyoung | - |
dc.contributor.author | Hong, Da Hye | - |
dc.contributor.author | Choi, Il-Whan | - |
dc.contributor.author | Kim, Dae-Joong | - |
dc.contributor.author | Lee, Haena | - |
dc.contributor.author | Bang, Hyoweon | - |
dc.contributor.author | Na, Sung Hun | - |
dc.contributor.author | Li, Hongliang | - |
dc.contributor.author | Jo, Su-Hyun | - |
dc.contributor.author | Park, Won Sun | - |
dc.date.available | 2019-03-09T01:38:08Z | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1537-1891 | - |
dc.identifier.issn | 1879-3649 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14354 | - |
dc.description.abstract | The effect of efonidipine, a commercially available antihypertensive drug and Ca2+ channel inhibitor, on voltage-dependent K+ (Kv) channels was studied in freshly isolated rabbit coronary arterial smooth muscle cells using the whole-cell patch clamp technique. The amplitude of Kv current was decreased by application of efonidipine in a dose-dependent manner, with IC50 of 026 mu M and a Hill coefficient of 0.91, which suggests 1:1 binding stoichiometry. Efonidipine did not affect voltage-dependent activation of the Kv channel, but shifted the inactivation curve by -8.87 my. The inhibitory effect of efonidipine was not significantly changed by depletion of extracellular Ca2+ or intracellular ATP, which indicated no involvement of the Ca2+ channel or intracellular protein kinase-dependent cascades. We conclude that efonidipine dose-dependently inhibits Kv current in a phosphorylation- and Ca2+ channel-independent manner. (C) 2013 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | The Ca2+ channel inhibitor efonidipine decreases voltage-dependent K+ channel activity in rabbit coronary arterial smooth muscle cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.vph.2013.07.005 | - |
dc.identifier.bibliographicCitation | VASCULAR PHARMACOLOGY, v.59, no.3-4, pp 90 - 95 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000326058200006 | - |
dc.identifier.scopusid | 2-s2.0-84885324492 | - |
dc.citation.endPage | 95 | - |
dc.citation.number | 3-4 | - |
dc.citation.startPage | 90 | - |
dc.citation.title | VASCULAR PHARMACOLOGY | - |
dc.citation.volume | 59 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Efonidipine | - |
dc.subject.keywordAuthor | Voltage-dependent K+ channels | - |
dc.subject.keywordAuthor | Coronary artery | - |
dc.subject.keywordPlus | RAT VENTRICULAR MYOCYTES | - |
dc.subject.keywordPlus | T-TYPE | - |
dc.subject.keywordPlus | CALCIUM-CHANNELS | - |
dc.subject.keywordPlus | BLOCK | - |
dc.subject.keywordPlus | ANTAGONISTS | - |
dc.subject.keywordPlus | NIFEDIPINE | - |
dc.subject.keywordPlus | MIBEFRADIL | - |
dc.subject.keywordPlus | VERAPAMIL | - |
dc.subject.keywordPlus | CURRENTS | - |
dc.subject.keywordPlus | KV1.5 | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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