Synergistic effect of a novel cyclic pentadepsipeptide, neoN-methylsansalvamide, and paclitaxel on human multidrug resistance cancer cell lines
DC Field | Value | Language |
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dc.contributor.author | Lee, Hee-Seok | - |
dc.contributor.author | Phat, Chanvorleak | - |
dc.contributor.author | Choi, Sang-Un | - |
dc.contributor.author | Lee, Chan | - |
dc.date.available | 2019-03-09T01:43:18Z | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 0959-4973 | - |
dc.identifier.issn | 1473-5741 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14562 | - |
dc.description.abstract | NeoN-methylsansalvamide is a novel low-molecular- weight cyclic pentadepsipeptide that exerts cytotoxic effects on various human cancer cell lines. Its structural analysis using liquid chromatography mass/mass spectrometry showed the cyclic structure sequence -phenylalanineleucine- valine-N-methylleucine-leucic acid-. The intrinsic cytotoxic and multidrug resistance reversal effects of neoN-methylsansalvamide were evaluated on the human cancer cell lines MES-SA and HCT15 as well as on their multidrug resistance sublines (MES-SA/DX5 and HCT15/CL05, respectively) using the sulforhodamine B assay. The EC50 values of paclitaxel for MES-SA, HCT15, and for the multidrug resistance sublines MES-SA/DX5 and HCT15/CL05 were 1.00 +/- 0.20, 0.85 +/- 0.63, 10.00 +/- 0.53, and > 1000 nmol/l, respectively. However, the EC50 values for paclitaxel including 3 lmol/l neoN-methylsansalvamide for MES-SA/DX5, HCT15, and HCT15/CL02 were 1.58 +/- 0.12, 0.10 +/- 0.02, and 288.40 +/- 21.02 nmol/l, respectively. The in-vitro multidrug resistance reversal activity of neoN-methylsansalvamide was similar to that of the control verapamil. These finding suggests that a novel cyclic pentadepsipeptide, neoN-methylsansalvamide, is effective in reversing multidrug resistance in vitro, and this activity may be a major applicable biological function of this compound. Anti-Cancer Drugs 24:455-460 (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. Anti-Cancer Drugs 2013, 24:455-460 | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Synergistic effect of a novel cyclic pentadepsipeptide, neoN-methylsansalvamide, and paclitaxel on human multidrug resistance cancer cell lines | - |
dc.type | Article | - |
dc.identifier.doi | 10.1097/CAD.0b013e32835f060d | - |
dc.identifier.bibliographicCitation | ANTI-CANCER DRUGS, v.24, no.5, pp 455 - 460 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000317392100003 | - |
dc.identifier.scopusid | 2-s2.0-84875872436 | - |
dc.citation.endPage | 460 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 455 | - |
dc.citation.title | ANTI-CANCER DRUGS | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | LC-MS/MS | - |
dc.subject.keywordAuthor | modulator | - |
dc.subject.keywordAuthor | multidrug resistance | - |
dc.subject.keywordAuthor | neoN-methylsansalvamide | - |
dc.subject.keywordPlus | ENNIATIN-H | - |
dc.subject.keywordPlus | N-METHYLSANSALVAMIDE | - |
dc.subject.keywordPlus | STRUCTURAL-ANALYSIS | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | GENUS FUSARIUM | - |
dc.subject.keywordPlus | MARINE FUNGUS | - |
dc.subject.keywordPlus | KFCC 11363P | - |
dc.subject.keywordPlus | BEAUVERICIN | - |
dc.subject.keywordPlus | DEPSIPEPTIDE | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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