Postoperative-stimulated serum thyroglobulin measured at the time of I-131 ablation is useful for the prediction of disease status in patients with differentiated thyroid carcinoma
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji In | - |
dc.contributor.author | Chung, Yun Jae | - |
dc.contributor.author | Cho, Bo Youn | - |
dc.contributor.author | Chong, SeMin | - |
dc.contributor.author | Seok, Ju Won | - |
dc.contributor.author | Park, Sung Jun | - |
dc.date.available | 2019-03-09T01:56:32Z | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 0039-6060 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14589 | - |
dc.description.abstract | Background. This study was conducted to identify the relevant cutoff value and to evaluate the usefulness of postoperative-stimulated serum thyroglobulin (Tg) at the time of I-131 ablation for the prediction of disease status in patients with differentiated thyroid carcinoma (DTC) who received high-dose I-131 ablation therapy after total thyroidectomy. Methods. We analyzed 218 consecutively enrolled patients who were diagnosed with DTC and underwent total thyroidectomy. All patients underwent I-131 ablation at. doses of 100-200 mCi, and. stimulated serum Tg was measured ai the time of I-131 ablation therapy. To assess disease-free status after I-131 ablation therapy, stimulated serum Tg levels, diagnostic whole-body scan (DxWBS) and. neck ultrasonography (US) were performed 6-12 months after I-131 ablation. Results. The relevant cutoff value of postoperative stimulated Tg for the prediction of disease-free status was 2 ng/mL. A total of 138 patients (63.3%) showed values of <2 ng/mL. Postoperative-stimulated Tg < 2 ng/mL had a negative piedictive value of 94.9%, which increased to 97.7% when low Tg was combined with negative neck US findings. Conclusion. Postoperative-stimulated Tg at the time of I-131 remnant ablation is a useful biochemical marker for the prediction of disease status in patients with DTC. When high-dose I-131 remnant ablation is performed after total thyroidectOmy, the stimulated Tg measurement and DxWBS that are usually performed 6-12 months after I-131 ablation therapy may be skipped, at least in low- and intermediate-risk patients with postoperative stimulated Tg of < 2 ng/mL and negative neck US findings. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.title | Postoperative-stimulated serum thyroglobulin measured at the time of I-131 ablation is useful for the prediction of disease status in patients with differentiated thyroid carcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.surg.2012.12.008 | - |
dc.identifier.bibliographicCitation | SURGERY, v.153, no.6, pp 828 - 835 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000319891400011 | - |
dc.identifier.scopusid | 2-s2.0-84878017954 | - |
dc.citation.endPage | 835 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 828 | - |
dc.citation.title | SURGERY | - |
dc.citation.volume | 153 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | LOW-RISK PATIENTS | - |
dc.subject.keywordPlus | MONITORING METHOD | - |
dc.subject.keywordPlus | CONSENSUS REPORT | - |
dc.subject.keywordPlus | CANCER PATIENTS | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | PAPILLARY | - |
dc.subject.keywordPlus | METASTASES | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | ULTRASONOGRAPHY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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