Cytotoxic Activity and Quantitative Structure Activity Relationships of Arylpropyl Sulfonamides
DC Field | Value | Language |
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dc.contributor.author | Hwang, Yu Jin | - |
dc.contributor.author | Park, Sang Min | - |
dc.contributor.author | Yim, Chul Bu | - |
dc.contributor.author | Im, Chaeuk | - |
dc.date.available | 2019-03-09T01:57:28Z | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14626 | - |
dc.description.abstract | B13 is a ceramide analogue and apoptosis inducer with potent cytotoxic activity. A series of arylpropyl sulfonamide analogues of B13 were evaluated for their cytotoxicity using MTT assays in prostate cancer PC-3 and leukemia HL-60 cell lines. Some compounds (4, 9, 13, 14, 15, and 20) showed stronger activities than B13 in both tumor cell lines, and compound (15) gave the most potent activity with IC50 values of 29.2 and 20.7 mu M, for PC-3and HL-60 cells, respectively. Three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis was performed to build highly reliable and predictive CoMSIA models with cross-validated q(2) values of 0.816 and 0.702, respectively. Our results suggest that long alkyl chains and a 1R, 2R configuration of the propyl group are important for the cytotoxic activities of arylpropyl sulfonamides. Moreover, the introduction of small hydrophobic groups in the phenyl ring and sulfonamide group could increase biological activity. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | Cytotoxic Activity and Quantitative Structure Activity Relationships of Arylpropyl Sulfonamides | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2013.17.3.237 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.17, no.3, pp 237 - 243 | - |
dc.identifier.kciid | ART001785762 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000323095200009 | - |
dc.identifier.scopusid | 2-s2.0-84880362199 | - |
dc.citation.endPage | 243 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 237 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 17 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Arylpropanol | - |
dc.subject.keywordAuthor | Ceramide | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | QSAR | - |
dc.subject.keywordPlus | PROSTATE-CANCER CELLS | - |
dc.subject.keywordPlus | LONG-CHAIN CERAMIDE | - |
dc.subject.keywordPlus | HUMAN COLON-CANCER | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | ENDOGENOUS CERAMIDE | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | DEATH | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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