3 ',4 '-Dimethoxythioflavone induces endothelium-dependent vasorelaxation through activation of epidermal growth factor receptor
DC Field | Value | Language |
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dc.contributor.author | Jang, Eun Jin | - |
dc.contributor.author | Seok, Young Mi | - |
dc.contributor.author | Lee, Jae In | - |
dc.contributor.author | Cho, Hyun Min | - |
dc.contributor.author | Sohn, Uy Dong | - |
dc.contributor.author | Kim, In Kyeom | - |
dc.date.available | 2019-03-09T01:59:56Z | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 0028-1298 | - |
dc.identifier.issn | 1432-1912 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14724 | - |
dc.description.abstract | It is of interest to investigate whether synthetic thioflavonoids have vasorelaxant actions as natural flavonoids. We tested the hypothesis that 3',4'-dimethoxythioflavone induces endothelium-dependent vasorelaxation through activation of epidermal growth factor (EGF) receptor. Rat aortic rings were mounted in organ baths and subjected to relaxation upon contraction. 3',4'-Dimethoxythioflavone induced endothelium-dependent vasorelaxation, which was attenuated by pretreatment with either l-N (omega)-nitroarginine methyl ester, an inhibitor of nitric oxide synthase, or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, an inhibitor of soluble guanylate cyclase. 3',4'-Dimethoxythioflavone-induced vasorelaxation was not affected by pretreatment with a general estrogen receptor antagonist ICI 182,780, a selective estrogen receptor-alpha antagonist methyl-piperidino-pyrazole dihydrochloride, or a G protein-coupled receptor 30 antagonist G15. However, pretreatment with EGF receptor blockers AG1478 or DAPH, but not with a phosphatidylinositol-3 kinase inhibitor LY294002 or an Akt1/2 kinase inhibitor Akt inhibitor VIII, attenuated 3',4'-dimethoxythioflavone-induced vasorelaxation. In addition, pretreatment with a Src inhibitor PP2 or an ERK inhibitor U0126 also attenuated vascular relaxation induced by the cumulative addition of 3',4'-dimethoxythioflavone. However, neither a mitochondrial electron transport inhibitor rotenone, an NADPH oxidase inhibitor apocynin, nor a superoxide dismutase mimetic MnTMPyP affected the vascular relaxation induced by the cumulative addition of 3',4'-dimethoxythioflavone. In conclusion, 3',4'-dimethoxythioflavone induces endothelium-dependent vasorelaxation through activation of EGF receptor and Src/ERK pathway in rat aorta. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | 3 ',4 '-Dimethoxythioflavone induces endothelium-dependent vasorelaxation through activation of epidermal growth factor receptor | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s00210-012-0818-z | - |
dc.identifier.bibliographicCitation | NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v.386, no.4, pp 339 - 350 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000316271500009 | - |
dc.identifier.scopusid | 2-s2.0-84876407415 | - |
dc.citation.endPage | 350 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 339 | - |
dc.citation.title | NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | - |
dc.citation.volume | 386 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | 3 ',4 '-Dimethoxythioflavone | - |
dc.subject.keywordAuthor | Endothelium-dependent vasorelaxation | - |
dc.subject.keywordAuthor | EGF receptor | - |
dc.subject.keywordAuthor | Src/ERK pathway | - |
dc.subject.keywordPlus | KINASE SIGNALING PATHWAY | - |
dc.subject.keywordPlus | VASCULAR SMOOTH-MUSCLE | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | EGF RECEPTOR | - |
dc.subject.keywordPlus | HYPERPOLARIZING FACTOR | - |
dc.subject.keywordPlus | THORACIC AORTA | - |
dc.subject.keywordPlus | RELAXATION | - |
dc.subject.keywordPlus | SRC | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | TRANSACTIVATION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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