Effect of Rice Cell-Derived Human Granulocyte-Macrophage Colony-Stimulating Factor on 5-Fluorouracil-Induced Mucositis in Hamsters
DC Field | Value | Language |
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dc.contributor.author | Won, Jong Hoon | - |
dc.contributor.author | Ji, Jung Eun | - |
dc.contributor.author | Ahn, Kyong Hoon | - |
dc.contributor.author | Kim, Seok Kyun | - |
dc.contributor.author | Choi, Jong Min | - |
dc.contributor.author | Ha, Hae Chan | - |
dc.contributor.author | Kim, Hye Mi | - |
dc.contributor.author | Yun, Chang Koo | - |
dc.contributor.author | Han, Kyuboem | - |
dc.contributor.author | Kim, Dae Kyong | - |
dc.date.available | 2019-03-09T02:02:00Z | - |
dc.date.issued | 2013-03 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.issn | 1347-5215 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14800 | - |
dc.description.abstract | Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important regulator of the maturation and function of cells in the granulocyte and macrophage lineages, and also plays a significant role in wound healing. In a previous study, we expressed human GM-CSF in rice cells (rice cell-derived human GM-CSF; rhGM-CSF). The purpose of the present study was to evaluate its effect on wound healing in oral mucositis. Oral mucositis was induced in Syrian hamster cheek pouches by 5-fluorouracil treatment and mechanical scratching. Ulcerated areas were treated from days 3 to 14 with an application of 200 mu L saline, or of the same volume of a solution containing 0.04, 0.2, or 1 mu g/mL rhGM-CSF. Treatment of hamsters with rhGM-CSF reduced the ulcerated areas of the oral mucosa, compared with the control. Early in the healing process, the mucositis tissue layer of the rhGM-CSF-treated group showed significantly decreased myeloper-oxidase activity and increased numbers of proliferating cell nuclear antigen (PCNA)-positive cells. Treatment with rhGM-CSF also affected expression of inflammatory cytokines in the ulcerative mucosal tissue. These results demonstrate the efficacy of plant-produced rhGM-CSF in wound healing and have significant implications for the development of rhGM-CSF as a therapeutic agent for ulcerative oral mucositis. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.title | Effect of Rice Cell-Derived Human Granulocyte-Macrophage Colony-Stimulating Factor on 5-Fluorouracil-Induced Mucositis in Hamsters | - |
dc.type | Article | - |
dc.identifier.doi | 10.1248/bpb.b12-00869 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.36, no.3, pp 425 - 431 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000315472500015 | - |
dc.identifier.scopusid | 2-s2.0-84875518144 | - |
dc.citation.endPage | 431 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 425 | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 36 | - |
dc.type.docType | Article | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | granulocyte-macrophage colony-stimulating factor | - |
dc.subject.keywordAuthor | mucositis | - |
dc.subject.keywordAuthor | wound healing | - |
dc.subject.keywordAuthor | hamster buccal pouch | - |
dc.subject.keywordAuthor | plant-based expression system | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | GM-CSF | - |
dc.subject.keywordPlus | TRANSGENIC PLANTS | - |
dc.subject.keywordPlus | FACTOR-ALPHA | - |
dc.subject.keywordPlus | ORAL MUCOSITIS | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | GLYCOSYLATION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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