Tartary buckwheat improves cognition and memory function in an in vivo amyloid-beta-induced Alzheimer model

Abstract

Protective effects of Tartary buckwheat (TB) and common buckwheat (CB) on amyloid beta (A beta)-induced impairment of cognition and memory function were investigated in vivo in order to identify potential therapeutic agents against Alzheimer's disease (AD) and its associated progressive memory deficits, cognitive impairment, and personality changes. An in vivo mouse model of AD was created by injecting the brains of ICR mice with A beta(25-35), a fragment of the full-length A beta protein. Damage of mice recognition ability through following A beta(25-35) brain injections was confirmed using the T-maze test, the object recognition test, and the Morris water maze test. Results of behavior tests in AD model showed that oral administration of the methanol (MeOH) extracts of TB and CB improved cognition and memory function following A beta(25-35) injections. Furthermore, in groups receiving the MeOH extracts of TB and CB, lipid peroxidation was significantly inhibited, and nitric oxide levels in tissue, which are elevated by injection of A beta(25-35), were also decrease. In particular, the MeOH extract of TB exerted a stronger protective activity than CB against A beta(25-35)-induced memory and cognition impairment. The results indicate that TB may play a promising role in preventing or reversing memory and cognition loss associated with A beta(25-35)-induced AD. (c) 2012 Elsevier Ltd. All rights reserved.