Anti-gastritis and wound healing effects of Momordicae Semen extract and its active component
DC Field | Value | Language |
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dc.contributor.author | Jung, Kiwon | - |
dc.contributor.author | Chin, Young-Won | - |
dc.contributor.author | Chung, Yoon Hee | - |
dc.contributor.author | Park, Yang Hae | - |
dc.contributor.author | Yoo, Hunseung | - |
dc.contributor.author | Min, Dong Sun | - |
dc.contributor.author | Lee, Bongyong | - |
dc.contributor.author | Kim, Jinwoong | - |
dc.date.available | 2019-03-09T02:03:53Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 0892-3973 | - |
dc.identifier.issn | 1532-2513 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14869 | - |
dc.description.abstract | Momordicae Semen, Momordica cochinchinensis Springer (Cucurbitaceae), has long been known to effectively relieve boils, rheumatic pain, and hemorrhoids. In this study, we investigated whether Momordicae Semen extract (MSE) has anti-gastritis effects in various rodent models and also explored possible mechanisms for the gastroprotective effects of MSE. MSE provided remarkable protective effects, comparable to those of rebamipide, in ethanol-and diclofenac-induced acute gastritis. In addition, it has demonstrated protective effect in a Helicobacter pylori-insulted chronic gastritis model. MSE also showed wound healing effect on cutaneous injury of mice and stimulated calcitonin gene-related peptide and somatostatin receptors, which may be related to its anti-gastritis effects. In a single oral dose toxicity study, the approximate lethal dose of MSE was determined at >2000 mg/kg/day. The NOAEL was set to be 2000 mg/kg/day from the repeated oral dose toxicity study. Moreover, momordica saponin I, a major ingredient of MSE, treatment decreased gastric mucosa damage indices in the ethanol- and diclofenac-induced acute gastritis models. The results suggest that MSE could be a promising gastroprotective herbal medicine and momordica saponin I might be used as an active marker compound for MSE. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Anti-gastritis and wound healing effects of Momordicae Semen extract and its active component | - |
dc.type | Article | - |
dc.identifier.doi | 10.3109/08923973.2012.712139 | - |
dc.identifier.bibliographicCitation | IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, v.35, no.1, pp 126 - 132 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000312505400017 | - |
dc.identifier.scopusid | 2-s2.0-84869179141 | - |
dc.citation.endPage | 132 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 126 | - |
dc.citation.title | IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | - |
dc.citation.volume | 35 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Momordicae Semen | - |
dc.subject.keywordAuthor | anti-gastritis | - |
dc.subject.keywordAuthor | wound healing | - |
dc.subject.keywordAuthor | calcitonin gene-related peptide | - |
dc.subject.keywordAuthor | somatostatin | - |
dc.subject.keywordAuthor | momordica saponin I | - |
dc.subject.keywordPlus | GENE-RELATED PEPTIDE | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI | - |
dc.subject.keywordPlus | H-2-RECEPTOR ANTAGONIST | - |
dc.subject.keywordPlus | COCHINCHINENSIS SPRENG | - |
dc.subject.keywordPlus | ERADICATION THERAPY | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | ULCER | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | ETHANOL | - |
dc.subject.keywordPlus | SOMATOSTATIN | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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