Beneficial Effects of the Mixed Adjuvant of CpG plus Monophosphoryl Lipid A in Immunization with a Recombinant Protein Vaccine for Hepatitis A
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Inkyu | - |
dc.contributor.author | Choi, Daewoon | - |
dc.contributor.author | See, Hyejeong | - |
dc.contributor.author | Kim, Wonyong | - |
dc.contributor.author | Chung, In Sik | - |
dc.contributor.author | Shon, Dong-Hwa | - |
dc.date.available | 2019-03-09T02:37:13Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 1738-2203 | - |
dc.identifier.issn | 2468-0842 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14916 | - |
dc.description.abstract | In an effort to develop a new vaccine for hepatitis A, which is mainly transmitted via contaminated foods and water, recombinant virus protein 1 (VP1) of hepatitis A virus was used as an antigen. Several adjuvants in a single or a mixed form, i.e., alum, CpG oligodeoxynucleotide, monophosphoryl lipid A (MPL), alum plus MPL, and CpG plus MPL, were also tested for their immunological properties. When their effects on the production of VP1-specific IgG relative to that of total IgG and the levels of and balance between Th1- and Th2-type cytokine productions were compared, CpG plus MPL was found to have highly beneficial effects, providing a new insight in selection of adjuvant for development of a new vaccine. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY | - |
dc.title | Beneficial Effects of the Mixed Adjuvant of CpG plus Monophosphoryl Lipid A in Immunization with a Recombinant Protein Vaccine for Hepatitis A | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s13765-012-2398-5 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.56, no.1, pp 95 - 98 | - |
dc.identifier.kciid | ART001744020 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000316505400015 | - |
dc.identifier.scopusid | 2-s2.0-84874290643 | - |
dc.citation.endPage | 98 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 95 | - |
dc.citation.title | JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 56 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | adjuvant | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | hepatitis A | - |
dc.subject.keywordAuthor | immunoglobulin | - |
dc.subject.keywordAuthor | recombinant vaccine | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ALUMINUM | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | IL-10 | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.