Osteopontin expression in papillary thyroid carcinoma and its relationship with the BRAF mutation and tumor characteristics
DC Field | Value | Language |
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dc.contributor.author | Kang, Kyung Ho | - |
dc.date.available | 2019-03-09T02:38:49Z | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 2233-7903 | - |
dc.identifier.issn | 2093-0488 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14983 | - |
dc.description.abstract | Purpose: We evaluated the relationship between the degree of osteopontin (OPN) expression in papillary thyroid carcinoma (PTC) specimens and the presence of the BRAF mutation and clinicopathologic variables. Methods: Fifty-six snap-frozen thyroid tumor samples, including those of 49 PTCs, four follicular adenomas, two follicular carcinomas, and one Hurthle cell adenoma, were studied. We performed reverse transcription-polymerase chain reaction (RT-PCR) to assess the OPN expression levels. We also tested the BRAF codon 599 mutations using RT-PCR with the direct sequencing method. All of the tumors were microscopically reexamined by a pathologist with a special interest in thyroid neoplasia. Results: OPN mRNA was significantly overexpressed in the PTC samples compared with other thyroid tumors (P = 0.011). In PTCs, the OPN expression level was higher in the BRAF mutation group than in the wild-type group (P = 0.041). Among the clinicopathologic variables, nonfollicular variant histologic subtypes (P = 0.002) and the presence of lymph node metastases (P = 0.042) were correlated with elevated level of OPN expression. Conclusion: OPN might play a crucial role in tumorigenesis and the progression of PTC. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SURGICAL SOCIETY | - |
dc.title | Osteopontin expression in papillary thyroid carcinoma and its relationship with the BRAF mutation and tumor characteristics | - |
dc.type | Article | - |
dc.identifier.doi | 10.4174/jkss.2013.84.1.9 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE KOREAN SURGICAL SOCIETY, v.84, no.1, pp 9 - 17 | - |
dc.identifier.kciid | ART001720887 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000313396100002 | - |
dc.identifier.scopusid | 2-s2.0-84874714412 | - |
dc.citation.endPage | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9 | - |
dc.citation.title | JOURNAL OF THE KOREAN SURGICAL SOCIETY | - |
dc.citation.volume | 84 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Osteoponin | - |
dc.subject.keywordAuthor | Papillary thyroid cancer | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | FOLLICULAR VARIANT | - |
dc.subject.keywordPlus | HIGH PREVALENCE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | RAS | - |
dc.subject.keywordPlus | RET | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordPlus | ONCOGENE | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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