A long-term outcome of therapeutic angiogenesis by transplantation of peripheral blood stem cells in critical limb ischemia after interventional revascularization
- Authors
- Reddy, Alavala Matta; Kwak, Byung Kook; Shim, Hyung Jin; Jang, Eui-Chan; Park, Ae Ja; Park, Eunkyung; Ahn, Chiyoung
- Issue Date
- Jan-2013
- Publisher
- TURKISH SOC RADIOLOGY
- Citation
- DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY, v.19, no.1, pp 76 - 80
- Pages
- 5
- Journal Title
- DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
- Volume
- 19
- Number
- 1
- Start Page
- 76
- End Page
- 80
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14989
- DOI
- 10.4261/1305-3825.DIR.5877-12.2
- ISSN
- 1305-3825
1305-3612
- Abstract
- A 61-year-old male patient with atherosclerotic critical limb ischemia in the left leg underwent stent insertion into the left superficial femoral artery. Stenting procedures improved Rutherford grade from III-5 to II-4. Granulocyte colony-stimulating factor stimulated the production of white blood cells over four-fold and mononuclear cells (MNCs) 1.5-fold in the whole blood. Transplantation of 7.9x10(9) autologous MNCs into the left femoral artery rapidly decreased the leg pain intensity, with further improvement of Rutherford grades from II-4 to 0-0 without any side effects. In the four-year follow-up, significant improvement was found in terms of ankle brachial index, from nondetectable to 0.67, and peak systolic velocity, from 14.8 to 36.1 cm/s. Limb salvage and decreased resting pain were the notable outcomes of the treatment.
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