Reduced Expression of DKK3 Is Associated With Adverse Clinical Outcomes of Uterine Cervical Squamous Cell Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Ryu, Seok-Woo | - |
dc.contributor.author | Kim, Jae Hyung | - |
dc.contributor.author | Kim, Mi Kyung | - |
dc.contributor.author | Lee, Youn-Jeong | - |
dc.contributor.author | Park, Jun-Soo | - |
dc.contributor.author | Park, Hyoung-Moo | - |
dc.contributor.author | Kim, Dong-Ho | - |
dc.contributor.author | Lee, Sang-Hoon | - |
dc.contributor.author | Lee, Eun-Ju | - |
dc.date.available | 2019-03-09T02:39:03Z | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 1048-891X | - |
dc.identifier.issn | 1525-1438 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14992 | - |
dc.description.abstract | Objective: The aim of this study was to assess the expression of DKK3 protein and its target, beta-catenin, in uterine cervical squamous cell carcinoma and to determine potential clinical correlations. Materials and Methods: Six carcinoma in-situ (CIS) tissues and 88 invasive cervical cancer tissues were included in the study. Twenty-two normal cervical tissues and one gastric cancer tissue were used as controls. The expression of DKK3 and beta-catenin proteins was evaluated by immunohistochemical analysis. Clinical and pathological parameters were obtained from medical records. Survival data were estimated using Kaplan-Meier estimates and compared with a log-rank test. Multivariate analysis was performed using the Cox regression method. Results: DICK3 was predominantly present in the cytoplasm. Beta-catenin was observed only on the cellular membrane of both normal and cancer cells in contrast to earlier reports, in which beta-catenin was localized to the cytoplasm and nucleus of cancer cells. The expressions of beta-catenin and DKK3 were not correlated. Three of 6 CIS (50%) and 57 of 88 invasive cancer specimens (64.8%) had lower DKK3 expression than normal controls. DKK3 expression was decreased in a stage-dependent manner (P = 0.021). The patients with low expression of DKK3 were older than those with high expression of DKK3 (P < 0.01). Moreover, the patients with low DKK3 expression had a significantly lower 5-year disease-free survival rate than those with high DKK3 expression (P = 0.026). A multivariate analysis showed that International Federation of Gynecology and Obstetrics clinical stage and parametrial involvement were independent prognostic factors. Conclusion: Decreased DKK3 expression was associated with advanced International Federation of Gynecology and Obstetrics clinical stages and was predictive of lower disease-free survival in patients with cervical squamous cell carcinoma. DKK3 may be implicated in cervical carcinogenesis through a beta-catenin independent mechanism. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Reduced Expression of DKK3 Is Associated With Adverse Clinical Outcomes of Uterine Cervical Squamous Cell Carcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1097/IGC.0b013e3182754feb | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, v.23, no.1, pp 134 - 140 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000314005000019 | - |
dc.identifier.scopusid | 2-s2.0-84872354688 | - |
dc.citation.endPage | 140 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 134 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | - |
dc.citation.volume | 23 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Cervical cancer | - |
dc.subject.keywordAuthor | DKK3 | - |
dc.subject.keywordAuthor | Beta-catenin | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | PROMOTER-HYPERMETHYLATION | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | REIC/DKK-3 | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordPlus | BREAST | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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