Efficacy of levofloxacin versus cefuroxime in treating acute exacerbations of chronic obstructive pulmonary disease
DC Field | Value | Language |
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dc.contributor.author | Yoon, Ho Il | - |
dc.contributor.author | Lee, Chang-Hoon | - |
dc.contributor.author | Kim, Deog Kyeom | - |
dc.contributor.author | Park, Geun Min | - |
dc.contributor.author | Lee, Sang-Min | - |
dc.contributor.author | Yim, Jae-Joon | - |
dc.contributor.author | Kim, Jae-Yeol | - |
dc.contributor.author | Lee, Jae Ho | - |
dc.contributor.author | Lee, Choon-Taek | - |
dc.contributor.author | Chung, Hee Soon | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Han, Sung Koo | - |
dc.contributor.author | Yoo, Chul-Gyu | - |
dc.date.available | 2019-03-09T02:41:13Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1176-9106 | - |
dc.identifier.issn | 1178-2005 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/15080 | - |
dc.description.abstract | Background: Antibiotic treatment is one of the major pharmacologic treatments for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the choice of antibiotic depends on the local resistance pattern. A multicenter, randomized, controlled trial was done in patients with AECOPD to compare the efficacy of levofloxacin with that of cefuroxime axetil. Methods: Patients with AECOPD and without radiographic evidence of pneumonia were enrolled and randomized to either levofloxacin 500 mg daily or cefuroxime 250 mg twice daily in the mild-moderate exacerbation group, or 500 mg twice daily in the severe exacerbation group, for seven days. Clinical efficacy and microbiologic response were evaluated 5-7 days after the last dose. Results: Treatment was clinically successful in 90.4% of patients in the levofloxacin group, and in 90.6% of patients in the cefuroxime group (95% confidence interval -9.40 to 10.91), within a noninferiority margin of 10%. The microbiologic response appeared to be higher in the levofloxacin group, but the difference was not statistically significant. The safety profile was similar in both groups. Conclusion: Levofloxacin is not inferior to cefuroxime with regard to clinical efficacy in treating AECOPD. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.title | Efficacy of levofloxacin versus cefuroxime in treating acute exacerbations of chronic obstructive pulmonary disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.2147/COPD.S41749 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v.8, pp 329 - 334 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000321560500001 | - |
dc.identifier.scopusid | 2-s2.0-84880094917 | - |
dc.citation.endPage | 334 | - |
dc.citation.startPage | 329 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 뉴질랜드 | - |
dc.subject.keywordAuthor | chronic obstructive pulmonary disease | - |
dc.subject.keywordAuthor | acute exacerbation | - |
dc.subject.keywordAuthor | levofloxacin | - |
dc.subject.keywordAuthor | cefuroxime | - |
dc.subject.keywordPlus | REQUIRING MECHANICAL VENTILATION | - |
dc.subject.keywordPlus | PROTECTED SPECIMEN BRUSH | - |
dc.subject.keywordPlus | CHRONIC-BRONCHITIS | - |
dc.subject.keywordPlus | ANTIMICROBIAL RESISTANCE | - |
dc.subject.keywordPlus | CONTEMPORARY MANAGEMENT | - |
dc.subject.keywordPlus | ANTIBIOTIC-THERAPY | - |
dc.subject.keywordPlus | LUNG-FUNCTION | - |
dc.subject.keywordPlus | COPD | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | PNEUMONIAE | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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