Profile of Human beta-Defensins 1,2 and Proinflammatory Cytokines (TNF-alpha, IL-6) in Patients with Chronic Kidney Disease
DC Field | Value | Language |
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dc.contributor.author | Oh, Dong-Jin | - |
dc.contributor.author | Kim, Hye Ryoun | - |
dc.contributor.author | Lee, Mi-Kyung | - |
dc.contributor.author | Woo, Yo Seop | - |
dc.date.available | 2019-03-09T02:42:01Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 1420-4096 | - |
dc.identifier.issn | 1423-0143 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/15111 | - |
dc.description.abstract | Background/Aim: Our aim was to determine whether altered human beta-defensin (HBD), pro-inflammatory cytokines including interleukin (IL)-6 and tumor necrotic factor (TNF)-alpha could increase the risk of developing and exacerbation of chronic kidney disease (CKD), especially for patients with diabetic nephropathy (DN). Methods: Serum samples were obtained from 338 CKD patients and 88 sex, age-matched healthy controls. The concentrations of HBD-1 were assayed using an RIA kit. Serum levels of HBD-2, IL-6 and TNF-alpha were assayed using an ELISA kit. Results: Serum levels of HBD-1, IL-6 and TNF-alpha were significantly higher in CKD patients compared to healthy controls (P<0.05). HBD-1 levels were inversely related to estimated glomerular filtration rate (eGFR), which was the coefficient factor (beta = -0.357, P = 0.035) explaining the variability in HBD-1 in CKD. Diabetic nephropathy (DN) patients at stage 3-5 had significantly higher serum HBD-1 levels than non DN patients (P=0.00). Conclusion: Our data support the view that there is increased inflammation in CKD and DN. The inverse correlation between eGFR and serum HBD-1 which we observed is suggestive of a relationship between innate immunity and renal function and should be further investigated. Copyright (C) 2013 S. Karger AG, Basel | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER | - |
dc.title | Profile of Human beta-Defensins 1,2 and Proinflammatory Cytokines (TNF-alpha, IL-6) in Patients with Chronic Kidney Disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1159/000355740 | - |
dc.identifier.bibliographicCitation | KIDNEY & BLOOD PRESSURE RESEARCH, v.37, no.6, pp 602 - 610 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000329057200009 | - |
dc.identifier.scopusid | 2-s2.0-84891060448 | - |
dc.citation.endPage | 610 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 602 | - |
dc.citation.title | KIDNEY & BLOOD PRESSURE RESEARCH | - |
dc.citation.volume | 37 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Human beta defensins | - |
dc.subject.keywordAuthor | Innate immunity | - |
dc.subject.keywordAuthor | Pro-inflammatory cytokines | - |
dc.subject.keywordAuthor | Diabetic nephropathy | - |
dc.subject.keywordAuthor | Chronic kidney disease | - |
dc.subject.keywordPlus | INNATE IMMUNE-SYSTEM | - |
dc.subject.keywordPlus | HUMAN BETA-DEFENSIN-1 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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