Ultraviolet B-induced LGI3 secretion protects human keratinocytes
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung Hoon | - |
dc.contributor.author | Jeong, Yun-Mi | - |
dc.contributor.author | Kim, So-Young | - |
dc.contributor.author | Jeong, Hyo-Soon | - |
dc.contributor.author | Park, Kyoung-Chan | - |
dc.contributor.author | Baek, Kwang Jin | - |
dc.contributor.author | Kwon, Nyoun Soo | - |
dc.contributor.author | Yun, Hye-Young | - |
dc.contributor.author | Kim, Dong-Seok | - |
dc.date.available | 2019-03-09T02:43:10Z | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.issn | 1600-0625 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/15156 | - |
dc.description.abstract | Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6-trinitro-1-chlorobenzene (TNCB). The H1R antagonist olopatadine hydrochloride and/or the H4R antagonist JNJ7777120 was then administered. Combination therapy was more effective than H1R antagonist monotherapy. Serum IgE and levels of interleukin (IL)-4, IL-5 and IL-6 (Th2 cytokines) in eczematous lesions decreased with combined therapy. Combined therapy with H1R and H4R antagonists counteracts the disadvantages of each as monotherapeutic agents and potentially represents a new strategy for the treatment of chronic allergic contact dermatitis. | - |
dc.format.extent | 3 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Ultraviolet B-induced LGI3 secretion protects human keratinocytes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1600-0625.2012.01550.x | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL DERMATOLOGY, v.21, no.9, pp 716 - 718 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000307883900058 | - |
dc.identifier.scopusid | 2-s2.0-84865346644 | - |
dc.citation.endPage | 718 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 716 | - |
dc.citation.title | EXPERIMENTAL DERMATOLOGY | - |
dc.citation.volume | 21 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | chronic allergic contact dermatitis | - |
dc.subject.keywordAuthor | H1 receptor antagonist | - |
dc.subject.keywordAuthor | H4 receptor antagonist | - |
dc.subject.keywordPlus | CONTACT-DERMATITIS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ANTIHISTAMINES | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CHEMOTAXIS | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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