Transcriptional activity of paired homeobox Pax6 is enhanced by histone acetyltransferase Tip60 during mouse retina development
DC Field | Value | Language |
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dc.contributor.author | Kim, Chul-Hong | - |
dc.contributor.author | Kim, Jung-Woong | - |
dc.contributor.author | Jang, Sang-Min | - |
dc.contributor.author | An, Joo-Hee | - |
dc.contributor.author | Song, Ki-Hyun | - |
dc.contributor.author | Choi, Kyung-Hee | - |
dc.date.available | 2019-03-09T02:55:47Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/15196 | - |
dc.description.abstract | Pax6 is a member of the Pax family of transcription factors that contains a DNA binding paired-box and homeobox domain. In animals, including humans, Pax6 plays a key role in development, regulating organogenesis of the eye and brain. The current data show that histone acetyltransferase Tip60 physically interacts with Pax6 in developing post-natal day 4 (P4) mouse retinas. We also found that Tip60 binds with paired-domain of Pax6 using its chromo- and zinc-finger-containing regions, and that these protein interactions were needed for the effective full-transcriptional activation of Pax6. Furthermore, among the combinations of Pax6-target gene interactions using its two DNA binding domain, paired- and homeobox domain, Tip60 significantly enhanced the transcriptional activity of Pax6 on the paired-domain binding sequence (P6CON) containing reporter construct (pCON) than other homeo domain and chimera binding containing pP3 and pCON/P3 constructs. Taken together, these results suggest that Tip60 binds with Pax6 and that this physical interaction leads to the full-transcriptional activation of Pax6 during retina development. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Transcriptional activity of paired homeobox Pax6 is enhanced by histone acetyltransferase Tip60 during mouse retina development | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2012.06.126 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.424, no.3, pp 427 - 432 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000307618800011 | - |
dc.identifier.scopusid | 2-s2.0-84864777036 | - |
dc.citation.endPage | 432 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 427 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 424 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Pax6 | - |
dc.subject.keywordAuthor | Tip60 | - |
dc.subject.keywordAuthor | Retinogenesis | - |
dc.subject.keywordAuthor | Transcriptional regulation | - |
dc.subject.keywordAuthor | Protein-protein interaction | - |
dc.subject.keywordPlus | MISSENSE MUTATION | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | DNA-BINDING | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | HOMEODOMAIN | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | TRANSACTIVATION | - |
dc.subject.keywordPlus | ANIRIDIA | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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