Dipeptides Inhibit Melanin Synthesis in Mel-Ab Cells through Down-Regulation of Tyrosinase
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyun-e | - |
dc.contributor.author | Kim, Eun-Hyun | - |
dc.contributor.author | Choi, Hye-Ryung | - |
dc.contributor.author | Sohn, Uy Dong | - |
dc.contributor.author | Yun, Hye-Young | - |
dc.contributor.author | Baek, Kwang Jin | - |
dc.contributor.author | Kwon, Nyoun Soo | - |
dc.contributor.author | Park, Kyoung-Chan | - |
dc.contributor.author | Kim, Dong-Seok | - |
dc.date.available | 2019-03-09T02:56:26Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/15217 | - |
dc.description.abstract | This study investigated the effects of proline-serine (PS) and valine-serine (VS) dipeptides on melanogenesis in Mel-Ab cells. Proline-serine and VS significantly inhibited melanin synthesis in a concentration-dependent manner, though neither dipeptide directly inhibited tyrosinase activity in a cell-free system. Both PS and VS down-regulated the expression of microphthalmia-associated transcription factor (MITE) and tyrosinase. In a follow-up study also described here, the effects of these dipeptides on melanogenesis-related signal transduction were quantified. Specifically, PS and VS induced ERK phosphorylation, though they had no effect on phosphorylation of the cAMP response element binding protein (CREB). These data suggest that PS and VS inhibit melanogenesis through ERK phosphorylation and subsequent down-regulation of MITF and tyrosinase. Properties of these dipeptides are compatible with application as skin-whitening agents. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.title | Dipeptides Inhibit Melanin Synthesis in Mel-Ab Cells through Down-Regulation of Tyrosinase | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2012.16.4.287 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.16, no.4, pp 287 - 291 | - |
dc.identifier.kciid | ART001690362 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000307990200010 | - |
dc.identifier.scopusid | 2-s2.0-84865830352 | - |
dc.citation.endPage | 291 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 287 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 16 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Dipeptide | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | Melanogenesis | - |
dc.subject.keywordAuthor | MITF | - |
dc.subject.keywordAuthor | Tyrosinase | - |
dc.subject.keywordPlus | HUMAN MELANOCYTES | - |
dc.subject.keywordPlus | PEPTIDES | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | PIGMENTATION | - |
dc.subject.keywordPlus | MICROPHTHALMIA | - |
dc.subject.keywordPlus | MITF | - |
dc.subject.keywordPlus | MELANOGENESIS | - |
dc.subject.keywordPlus | SKIN | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.