Cyclic RGD-conjugated Pluronic (R) blending system for active, targeted drug delivery
DC Field | Value | Language |
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dc.contributor.author | Lim, Chaemin | - |
dc.contributor.author | Moon, Junseong | - |
dc.contributor.author | Sim, Taehoon | - |
dc.contributor.author | Hoang, Ngoc Ha | - |
dc.contributor.author | Won, Woong Roeck | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Oh, Kyungsoo | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.date.available | 2019-01-22T14:20:26Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1523 | - |
dc.description.abstract | Background: Blending micellar systems of different types of polymers has been proposed as an efficient approach for tailor-made drug formulations. The lamellar structure of hydrophobic polymers may provide a high drug loading capacity, and hydrophilic polymers may provide good colloidal stability. Methods: In this study, the anticancer model drug docetaxel was loaded onto a nanosized blending micellar system with two pluronics (L121/F127). To achieve increased antitumor activity, the cyclic arginine-glycine-aspartic acid tripeptide (cRGD) as an active tumor targeting ligand was conjugated to the blending system. Results: The docetaxel-loaded Pluronic blending system exhibited a higher drug loading capacity than that of F127 and showed high colloidal stability with a spherical structure. cRGD conjugates demonstrated enhanced drug cellular uptake and anticancer activity against alpha v beta 3 integrin-overexpressing U87MG cancer cells. In vivo animal imaging also revealed that the prepared cRGD-conjugated nanoparticles effectively accumulated at the targeted tumor site through an active and passive targeting strategy. Conclusion: Accordingly, the prepared nanosized system shows potential as a tailor-made, active targeting, nanomedicinal platform for anticancer therapy. We believe that this novel nanoplatform will provide insights for advancement of tumor therapy. | - |
dc.format.extent | 13 | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.title | Cyclic RGD-conjugated Pluronic (R) blending system for active, targeted drug delivery | - |
dc.type | Article | - |
dc.identifier.doi | 10.2147/IJN.S171794 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.13, pp 4627 - 4639 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000441176000006 | - |
dc.identifier.scopusid | 2-s2.0-85053323922 | - |
dc.citation.endPage | 4639 | - |
dc.citation.startPage | 4627 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 13 | - |
dc.type.docType | Article | - |
dc.publisher.location | 뉴질랜드 | - |
dc.subject.keywordAuthor | blending micellar system | - |
dc.subject.keywordAuthor | docetaxel | - |
dc.subject.keywordAuthor | cyclic RGD | - |
dc.subject.keywordAuthor | Pluronic L121/F127 | - |
dc.subject.keywordAuthor | active targeting | - |
dc.subject.keywordAuthor | nanomedicine | - |
dc.subject.keywordPlus | LIPID NANOPARTICLES | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | FORMULATIONS | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | NANOMEDICINES | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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