Development of a novel L-sulpiride-loaded quaternary microcapsule: Effect of TPGS as an absorption enhancer on physicochemical characterization and oral bioavailability
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dong Shik | - |
dc.contributor.author | Kim, Dong Wuk | - |
dc.contributor.author | Kim, Kyeong Soo | - |
dc.contributor.author | Choi, Jong Seo | - |
dc.contributor.author | Seo, Youn Gee | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.contributor.author | Jin, Sung Giu | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.date.available | 2019-01-22T14:21:45Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1628 | - |
dc.description.abstract | The aim of this study was to assess the effect of n-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) on the physicochemical characterization and oral bioavailability of a novel L-sulpiride-loaded quaternary microcapsule (QMC). The effect of carriers on drug solubility was investigated. Among the carriers tested, polyvinyl pyrrolidone (PVP), sodium lauryl sulphate (SLS) and TPGS were selected as polymer, surfactant and absorption enhancer, respectively, due to their high drug solubility. Using the solvent evaporation method, numerous QMCs with different ratios of L-sulpiride, PVP, SLS and TPGS were prepared, and their physicochemical properties, solubility and release were evaluated. In addition, the influence of TPGS concentration on the oral bioavailability of various drug doses was evaluated. All QMCs converted the crystalline drug to the amorphous form and remarkably improved the solubility, release and oral bioavailability of the drug. Furthermore, the TPGS concentration in the QMCs hardly affected the crystallinity, particle size and release, but considerably increased the solubility and oral bioavailability of the drug. In particular, as the dose of administered drug was increased, TPGS provided a greater improvement in oral drug bioavailability. Thus, TPGS played an important role in improving the oral bioavailability of L-sulpiride. Moreover, the QMC with a drug/PVP/SLS/TPGS weight ratio of 5:12:1 :20 with approximately 3.3-fold improved oral bioavailability would be recommended as a commercial pharmaceutical product for oral administration of L-sulpiride. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Development of a novel L-sulpiride-loaded quaternary microcapsule: Effect of TPGS as an absorption enhancer on physicochemical characterization and oral bioavailability | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.colsurfb.2016.08.010 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.147, pp 250 - 257 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000384851400029 | - |
dc.identifier.scopusid | 2-s2.0-84984799901 | - |
dc.citation.endPage | 257 | - |
dc.citation.startPage | 250 | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 147 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | L-sulpiride | - |
dc.subject.keywordAuthor | Quaternary microcapsule | - |
dc.subject.keywordAuthor | D-alpha-tocopheryl polyethylene glycol 1000 | - |
dc.subject.keywordAuthor | succinate | - |
dc.subject.keywordAuthor | Oral absorption | - |
dc.subject.keywordAuthor | Administered drug dose | - |
dc.subject.keywordPlus | IN-VIVO EVALUATION | - |
dc.subject.keywordPlus | BIOPHARMACEUTICS CLASSIFICATION-SYSTEM | - |
dc.subject.keywordPlus | DRUG-DELIVERY SYSTEM | - |
dc.subject.keywordPlus | VITAMIN-E TPGS | - |
dc.subject.keywordPlus | SOLID LIPID NANOPARTICLES | - |
dc.subject.keywordPlus | INTESTINAL-ABSORPTION | - |
dc.subject.keywordPlus | AQUEOUS SOLUBILITY | - |
dc.subject.keywordPlus | PARTICLE-SIZE | - |
dc.subject.keywordPlus | SOLUBLE DRUG | - |
dc.subject.keywordPlus | MODEL-DRUG | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.