Engineered self-expander hydrogel for sustained release of drug molecules
DC Field | Value | Language |
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dc.contributor.author | Kim, Jieun | - |
dc.contributor.author | Hwang, Jangsun | - |
dc.contributor.author | Seo, Youngmin | - |
dc.contributor.author | Jo, Yeonho | - |
dc.contributor.author | Son, Jaewoo | - |
dc.contributor.author | Paik, Taejong | - |
dc.contributor.author | Choi, Jonghoon | - |
dc.date.available | 2019-01-22T14:22:40Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.issn | 1876-794X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1674 | - |
dc.description.abstract | We synthesized a copolymer hydrogel composed of methyl methacrylate and N-vinyl-2-pyrrolidone and evaluated the in vitro release of the anticancer drug doxorubicin from this self-expanding hydrogel, under physiological conditions. The degree of expansion of the self-expanding copolymer was measured in various solutions. We induced drug adsorption into the methyl methacrylate and N-vinyl-2-pyrrolidone hydrogel by self-expansion, promoted by osmotic pressure. The antitumor effects of the released drug molecules were evaluated in MDA-MB-231 breast carcinoma cells. In conclusion, we provide evidence that this drug-containing self-expanding hydrogel may have the potential for biomedical applications including as an implant in tissue areas that require both physical support and anti-inflammatory drug treatment. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Engineered self-expander hydrogel for sustained release of drug molecules | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jiec.2016.07.033 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.42, pp 121 - 125 | - |
dc.identifier.kciid | ART002157130 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000384873100017 | - |
dc.identifier.scopusid | 2-s2.0-84991030759 | - |
dc.citation.endPage | 125 | - |
dc.citation.startPage | 121 | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 42 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Hydrogel | - |
dc.subject.keywordAuthor | Self-expander | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Doxorubicin | - |
dc.subject.keywordPlus | TISSUE EXPANSION | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | COMPLEXATION | - |
dc.subject.keywordPlus | NETWORKS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | SOCKET | - |
dc.subject.keywordPlus | ACID) | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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