Peroxiredoxin 6 expression is inversely correlated with nuclear factor-kappa B activation during Clonorchis sinensis infestation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pak, Jhang Ho | - |
dc.contributor.author | Son, Woo Chan | - |
dc.contributor.author | Seo, Sang-Beom | - |
dc.contributor.author | Hong, Sung-Jong | - |
dc.contributor.author | Sohn, Woon-Mok | - |
dc.contributor.author | Na, Byoung-Kuk | - |
dc.contributor.author | Kim, Tong-Soo | - |
dc.date.available | 2019-01-22T14:23:48Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.issn | 1873-4596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1773 | - |
dc.description.abstract | Clonorchis sinensis is a carcinogenic human liver fluke. Its infection promotes persistent oxidative stress and chronic inflammation environments in the bile duct and surrounding liver tissues owing to direct contact with worms and their excretory secretory products (ESPs), provoking epithelial hyperplasia, periductal fibrosis, and cholangiocarcinogenesis. We examined the reciprocal regulation of two ESP-induced redox-active proteins, NF-kappa B and peroxiredoxin 6 (Prdx6), during C sinensis infection. Prdx6 overexpression suppressed intracellular free-radical generation by inhibiting NADPH oxidase2 and inducible nitric oxide synthase activation in the ESP-treated cholangiocarcinoma cells, substantially attenuating NF-kappa B-mediated inflammation. NF-kappa B overexpression decreased Prdx6 transcription levels by binding to two kappa B sites within the promoter. This transcriptional repression was compensated for by other ESP-induced redox-active transcription factors, including erythroid 2-related factor 2 (Nrf2), hypoxia inducible factor 1 alpha (HIF1 alpha), and CCAAT/enhancer-binding protein beta (C/EBP beta). Distribution of immunoreactive Prdx6 and NF-kappa B was distinct in the early stages of infection in mouse livers but shared concomitant localization in the later stages. The intensity and extent of their immunoreactive staining in infected mouse livers are proportional to lesion severity and infection duration. The constitutive elevations of Prdx6 and NF-kappa B during C. sinensis infection may be associated with more severe persistent hepatobiliary abnormalities mediated by clonorchiasis. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 13 | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Peroxiredoxin 6 expression is inversely correlated with nuclear factor-kappa B activation during Clonorchis sinensis infestation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.freeradbiomed.2016.08.016 | - |
dc.identifier.bibliographicCitation | FREE RADICAL BIOLOGY AND MEDICINE, v.99, pp 273 - 285 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000387995400026 | - |
dc.identifier.scopusid | 2-s2.0-85008677022 | - |
dc.citation.endPage | 285 | - |
dc.citation.startPage | 273 | - |
dc.citation.title | FREE RADICAL BIOLOGY AND MEDICINE | - |
dc.citation.volume | 99 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Cholangiocarcinoma | - |
dc.subject.keywordAuthor | Clonorchis sinensis infection | - |
dc.subject.keywordAuthor | Excretory-secretory products, Prdx6, NF- κB | - |
dc.subject.keywordAuthor | Free radicals | - |
dc.subject.keywordAuthor | Redox-active transcription factors | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | NITRATIVE DNA-DAMAGE | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | 1-CYS PEROXIREDOXIN | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | OPISTHORCHIS-VIVERRINI | - |
dc.subject.keywordPlus | NADPH OXIDASE | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISM | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.