Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Im, Eun-Ju | - |
dc.contributor.author | Lee, Chan-Hyeong | - |
dc.contributor.author | Moon, Pyong-Gon | - |
dc.contributor.author | Rangaswamy, Gunassekaran Gowri | - |
dc.contributor.author | Lee, Byungheon | - |
dc.contributor.author | Lee, Jae Man | - |
dc.contributor.author | Lee, Jae-Chul | - |
dc.contributor.author | Jee, Jun-Goo | - |
dc.contributor.author | Bae, Jong-Sup | - |
dc.contributor.author | Kwon, Taeg-Kyu | - |
dc.contributor.author | Kang, Keon-Wook | - |
dc.contributor.author | Jeong, Myeong-Seon | - |
dc.contributor.author | Lee, Joo-Eun | - |
dc.contributor.author | Jung, Hyun-Suk | - |
dc.contributor.author | Ro, Hyun-Joo | - |
dc.contributor.author | Jun, Sangmi | - |
dc.contributor.author | Kang, Wonku | - |
dc.contributor.author | Seo, Seung-Yong | - |
dc.contributor.author | Cho, Young-Eun | - |
dc.contributor.author | Song, Byoung-Joon | - |
dc.contributor.author | Baek, Moon-Chang | - |
dc.date.available | 2019-05-28T01:33:35Z | - |
dc.date.issued | 2019-03-27 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18103 | - |
dc.description.abstract | Inhibitors of the secretion of cancer exosomes, which promote cancer progression and metastasis, may not only accelerate exosome biology research but also offer therapeutic benefits for cancer patients. Here we identify sulfisoxazole (SFX) as an inhibitor of small extracellular vesicles (sEV) secretion from breast cancer cells through interference with endothelin receptor A (ETA). SFX, an FDA-approved oral antibiotic, showed significant anti-tumor and anti-metastatic effects in mouse models of breast cancer xenografts, the reduced expression of proteins involved in biogenesis and secretion of sEV, and triggered co-localization of multivesicular endosomes with lysosomes for degradation. We demonstrate the important role of ETA, as target of SFX, by gain- and loss-of-function studies of the ETA protein, through a direct binding assay, and pharmacological and genetic approaches. These findings may provide a foundation for sEV-targeted cancer therapies and the mechanistic studies on sEV biology. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-019-09387-4 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.10, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000462458900002 | - |
dc.identifier.scopusid | 2-s2.0-85063439802 | - |
dc.citation.number | 1 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | CANCER EXOSOMES | - |
dc.subject.keywordPlus | BIOGENESIS | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ANTAGONISTS | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.