Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection
DC Field | Value | Language |
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dc.contributor.author | Zhou, Wenjun | - |
dc.contributor.author | He, Yanlin | - |
dc.contributor.author | Rehman, Atteeq U. | - |
dc.contributor.author | Kong, Yan | - |
dc.contributor.author | Hong, Sungguan | - |
dc.contributor.author | Ding, Guolian | - |
dc.contributor.author | Yalamanchili, Hari Krishna | - |
dc.contributor.author | Wan, Ying-Wooi | - |
dc.contributor.author | Paul, Basil | - |
dc.contributor.author | Wang, Chuhan | - |
dc.contributor.author | Gong, Yingyun | - |
dc.contributor.author | Zhou, Wenxian | - |
dc.contributor.author | Liu, Hao | - |
dc.contributor.author | Deans, John | - |
dc.contributor.author | Scalais, Emmanuel | - |
dc.contributor.author | O'Driscoll, Mary | - |
dc.contributor.author | Morton, Jenny E., V | - |
dc.contributor.author | Akawi, Nadia | - |
dc.contributor.author | Al-Turki, Saeed | - |
dc.contributor.author | Ambridge, Kirsty | - |
dc.contributor.author | Barrett, Jeffrey | - |
dc.contributor.author | Barrett, Daniel | - |
dc.contributor.author | Bayzetinova, Tanya | - |
dc.contributor.author | Carter, Nigel | - |
dc.contributor.author | Clayton, Stephen | - |
dc.contributor.author | Coomber, Eve | - |
dc.contributor.author | Firth, Helen | - |
dc.contributor.author | Fitzgerald, Tomas | - |
dc.contributor.author | FitzPatrick, David | - |
dc.contributor.author | Gerety, Sebastian | - |
dc.contributor.author | Gribble, Susan | - |
dc.contributor.author | Hurles, Matthew | - |
dc.contributor.author | Jones, Philip | - |
dc.contributor.author | Jones, Wendy | - |
dc.contributor.author | King, Daniel | - |
dc.contributor.author | Krishnappa, Netravathi | - |
dc.contributor.author | Mason, Laura | - |
dc.contributor.author | McRae, Jeremy | - |
dc.contributor.author | Michael, Parker | - |
dc.contributor.author | Middleton, Anna | - |
dc.contributor.author | Miller, Ray | - |
dc.contributor.author | Morley, Katherine | - |
dc.contributor.author | Parthiban, Vijaya | - |
dc.contributor.author | Prigmore, Elena | - |
dc.contributor.author | Rajan, Diana | - |
dc.contributor.author | Sifrim, Alejandro | - |
dc.contributor.author | Singh, Tarjinder | - |
dc.contributor.author | Tivery, Adrian | - |
dc.contributor.author | van Kogelenberg, Margriet | - |
dc.contributor.author | Wright, Caroline | - |
dc.contributor.author | Hou, Xinguo | - |
dc.contributor.author | Wu, Qi | - |
dc.contributor.author | Tong, Qingchun | - |
dc.contributor.author | Liu, Zhandong | - |
dc.contributor.author | Liu, Pengfei | - |
dc.contributor.author | Xu, Yong | - |
dc.contributor.author | Sun, Zheng | - |
dc.date.available | 2019-05-28T01:38:46Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 1097-6256 | - |
dc.identifier.issn | 1546-1726 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18266 | - |
dc.description.abstract | Nuclear receptor corepressor 1 (NCOR1) and NCOR2 (also known as SMRT) regulate gene expression by activating histone deacetylase 3 through their deacetylase activation domain (DAD). We show that mice with DAD knock-in mutations have memory deficits, reduced anxiety levels, and reduced social interactions. Mice with NCOR1 and NORC2 depletion specifically in GABAergic neurons (NS-V mice) recapitulated the memory deficits and had reduced GABA(A) receptor subunit alpha 2 (GABRA2) expression in lateral hypothalamus GABAergic (LHGABA) neurons. This was associated with LHGABA neuron hyperexcitability and impaired hippocampal long-term potentiation, through a monosynaptic LHGABA to CA3(GABA) projection. Optogenetic activation of this projection caused memory deficits, whereas targeted manipulation of LHGABA or CA3(GABA) neuron activity reversed memory deficits in NS-V mice. We describe de novo variants in NCOR1, NCOR2 or HDAC3 in patients with intellectual disability or neuro-developmental disorders. These findings identify a hypothalamus-hippocampus projection that may link endocrine signals with synaptic plasticity through NCOR-mediated regulation of GABA signaling. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41593-018-0311-1 | - |
dc.identifier.bibliographicCitation | NATURE NEUROSCIENCE, v.22, no.2, pp 205 - + | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000456750100007 | - |
dc.identifier.scopusid | 2-s2.0-85060487230 | - |
dc.citation.endPage | + | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 205 | - |
dc.citation.title | NATURE NEUROSCIENCE | - |
dc.citation.volume | 22 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | HISTONE DEACETYLASE 3 | - |
dc.subject.keywordPlus | RETT-SYNDROME | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | LTP INDUCTION | - |
dc.subject.keywordPlus | AGRP NEURONS | - |
dc.subject.keywordPlus | CO-REPRESSOR | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | HDAC3 | - |
dc.subject.keywordPlus | MECP2 | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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