A nano-complex system to overcome antagonistic photo-chemo combination cancer therapy
DC Field | Value | Language |
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dc.contributor.author | Lim, Chaemin | - |
dc.contributor.author | Moon, Junseong | - |
dc.contributor.author | Sim, Taehoon | - |
dc.contributor.author | Won, Woong Roeck | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.date.available | 2019-05-28T01:38:51Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.issn | 1873-4995 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18269 | - |
dc.description.abstract | Photo-Chemo combination therapy has been intensively investigated for treatment of cancers, especially multidrug resistance cancer. However, antagonistic interactions between chemo-drugs and photosensitizers are frequently reported, and drugs doses and treatment sequences have been changed to overcome the problems. We observed the antagonistic effect by a decrease in singlet oxygen generation from the photosensitizer when Dox was in close physical proximity. To control the distance between Dox and the photosensitizer, we developed a novel pH-sensitive poly ionomer complex system composed of PEG-PLL(-g-Ce6) [Chlorin e6 grafted poly(ethylene glycol)-poly(L-lysine)] and PEG-PLL(-g-DMA)-PLA [2,3-dimethylmaleic anhydride grafted poly(ethylene glycol)-poly(L-lysine)-poly(lactic acid)] and evaluated this system with regard to singlet oxygen generation and antiproliferative activity against MCF-7/Dox cells. Enhanced singlet oxygen generation and antiproliferative activities were observed in vitro and in vivo for the poly ionomer complex system compared to PEG-PLL(-g-Ce6)-PLA/Dox due to the change in distance between Dox and Ce6 in the PIC system under acidic conditions. Our results highlight the importance of interactions between co-loaded drugs in combination therapy, and provide new insights into design principles for tailor-made nanomedicine platforms. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | A nano-complex system to overcome antagonistic photo-chemo combination cancer therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jconrel.2018.12.043 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, v.295, pp 164 - 173 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000457149000015 | - |
dc.identifier.scopusid | 2-s2.0-85059461065 | - |
dc.citation.endPage | 173 | - |
dc.citation.startPage | 164 | - |
dc.citation.title | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.volume | 295 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Photo-chemo combination therapy | - |
dc.subject.keywordAuthor | Chlorin e6 | - |
dc.subject.keywordAuthor | Doxorubicin | - |
dc.subject.keywordAuthor | pH sensitive | - |
dc.subject.keywordAuthor | MDR | - |
dc.subject.keywordAuthor | Synergism | - |
dc.subject.keywordPlus | MEDIATED PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | PHOTOCHEMICAL INTERNALIZATION | - |
dc.subject.keywordPlus | SINGLET OXYGEN | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | NANOTECHNOLOGY | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | MICELLES | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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