Transferrin-Conjugated Polymeric Nanoparticle for Receptor-Mediated Delivery of Doxorubicin in Doxorubicin-Resistant Breast Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | Soe, Zar Chi | - |
dc.contributor.author | Kwon, Jun Bum | - |
dc.contributor.author | Thapa, Raj Kumar | - |
dc.contributor.author | Ou, Wenquan | - |
dc.contributor.author | Hanh Thuy Nguyen | - |
dc.contributor.author | Gautam, Milan | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Ku, Sae Kwang | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.date.available | 2019-05-28T01:39:32Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18293 | - |
dc.description.abstract | In this study, a transferrin (T-f)-conjugated polymeric nanoparticle was developed for the targeted delivery of the chemotherapeutic agent doxorubicin (Dox) in order to overcome multi-drug resistance in cancer treatment. Our objective was to improve Dox delivery for producing significant antitumor efficacy in Dox-resistant (R) breast cancer cell lines with minimum toxicity to healthy cells. The results of our experiments revealed that Dox was successfully loaded inside a transferrin (T-f)-conjugated polymeric nanoparticle composed of poloxamer 407 (F127) and 123 (P123) (Dox/F127&P123-T-f), which produced nanosized particles (similar to 90 nm) with a low polydispersity index (similar to 0.23). The accelerated and controlled release profiles of Dox from the nanoparticles were characterized in acidic and physiological pH and Dox/F127&P123-T-f enhanced Dox cytotoxicity in OVCAR-3, MDA-MB-231, and MDA-MB-231(R) cell lines through induction of cellular apoptosis. Moreover, Dox/F127&P123-T-f inhibited cell migration and altered the cell cycle patterns of different cancer cells. In vivo study in MDA-MB-231(R) tumor-bearing mice demonstrated enhanced delivery of nanoparticles to the tumor site when coated in a targeting moiety. Therefore, Dox/F127&P123-T-f has been tailored, using the principles of nanotherapeutics, to overcome drug-resistant chemotherapy. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Transferrin-Conjugated Polymeric Nanoparticle for Receptor-Mediated Delivery of Doxorubicin in Doxorubicin-Resistant Breast Cancer Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/pharmaceutics11020063 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICS, v.11, no.2 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000460799900015 | - |
dc.identifier.scopusid | 2-s2.0-85063124552 | - |
dc.citation.number | 2 | - |
dc.citation.title | PHARMACEUTICS | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | doxorubicin | - |
dc.subject.keywordAuthor | doxorubicin-resistant cancer | - |
dc.subject.keywordAuthor | polymeric nanoparticles | - |
dc.subject.keywordAuthor | transferrin | - |
dc.subject.keywordPlus | OVERCOMING MULTIDRUG-RESISTANCE | - |
dc.subject.keywordPlus | TARGETED CO-DELIVERY | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | HYBRID NANOPARTICLES | - |
dc.subject.keywordPlus | SEQUENTIAL DELIVERY | - |
dc.subject.keywordPlus | HISTONE DEACETYLASE | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | NANOCAPSULES | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | ENHANCE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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