Dendritic Cell-Targeted pH-Responsive Extracellular Vesicles for Anticancer Vaccination
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyuk | - |
dc.contributor.author | Park, Hongsuk | - |
dc.contributor.author | Yu, Hyeong Sup | - |
dc.contributor.author | Na, Kun | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.date.available | 2019-05-28T01:39:35Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18295 | - |
dc.description.abstract | Immunotherapy can potentially treat cancers on a patient-dependent manner. Most of the efforts expended on anticancer vaccination parallel the efforts expended on prototypical immunization in infectious diseases. In this study, we designed and synthesized pH-responsive extracellular vesicles (EVs) coupled with hyaluronic acid (HA), 3-(diethylamino)propylamine (DEAP), monophosphoryl lipid A (MPLA), and mucin 1 peptide (MUC1), referred to as HDEA@EVAT. HDEA@EVAT potentiated the differentiation and maturation of monocytes into dendritic cells (DCs) and the priming of CD8(+) T-cells for cancer therapy. MPLA and HA enabled HDEA@EVAT to interact with the toll-like receptor 4 and the CD44 receptor on DCs, followed by endosomal escape, owing to the protonation of pH-sensitive DEAP on the EV in conjunction with MUC1 release. The MUC1 was then processed and presented to DCs to activate CD8(+) T-cells for additional anticancer-related immune reactions. Our findings support the anticancer vaccine activity by which HDEA@EVAT expedites the interaction between DCs and CD8(+) T-cells by inducing DC-targeted maturation and by presenting the cancer-associated peptide MUC1. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Dendritic Cell-Targeted pH-Responsive Extracellular Vesicles for Anticancer Vaccination | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/pharmaceutics11020054 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICS, v.11, no.2 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000460799900006 | - |
dc.identifier.scopusid | 2-s2.0-85063155204 | - |
dc.citation.number | 2 | - |
dc.citation.title | PHARMACEUTICS | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | extracellular vesicles | - |
dc.subject.keywordAuthor | pH-responsive | - |
dc.subject.keywordAuthor | dendritic cells | - |
dc.subject.keywordAuthor | toll-like receptor 4 signaling | - |
dc.subject.keywordAuthor | anticancer vaccine | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | MATURE | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | TOLL | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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